Urticaria

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Summary of Urticaria

Urticaria, commonly referred to as hives, is a kind of skin rash notable for pale red, raised, itchy bumps. Urticaria may cause a burning or stinging sensation. Lesions are frequently caused by allergic reactions; however, there are many nonallergic causes. Most cases of hives lasting less than six weeks (acute urticaria) are the result of an allergic trigger. Chronic urticaria (hives lasting longer than six weeks) is rarely due to an allergy.

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Urticaria

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A 22-year-old woman comes to the clinic because of sensorineural deafness, recurrent urticaria, and a periodic fever. Physical examination shows a fever of 38.1° C, chills, and arthritis. It is discussed that possible treatment options are anakinra (IL-1 receptor antagonist), rilonacept (dimeric fusion protein,) or canakinumab (monoclonal antibody against IL-1 beta). The patient has a mutated CIAS1 gene (cryopyrin protein production). Which of the following is the most probable diagnosis for this patient?

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