Vaccinations: Clinical

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Vaccinations: Clinical

USMLE® Step 2 questions

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USMLE® Step 2 style questions USMLE

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An 18-year-old male patient comes to his pediatrician's office for a pre-college physical. He has no complaints within the past year, and review of systems is negative. He has a history of asthma controlled with an inhaled corticosteroid. He is not currently sexually active; he denies alcohol use and admits to using marijuana once weekly. There are no focal findings on physical examination. Which of the following preventive interventions is most appropriate for the patient at this point?


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Vaccination is the process of generating a protective adaptive immune response against microbes by exposing the body to non-pathogenic forms of microbes or components of microbes.

There are four main types of vaccines: Live attenuated, inactivated, subunit, and toxoid vaccines.

Live attenuated vaccines contain pathogens that have been weakened in the laboratory and they’re used to protect against Measles, Mumps, Rubella, and Varicella - the MMR-V vaccine, Rotavirus, polio- the Oral Polio Vaccine or OPV, influenza- the nasal flu vaccine and Yellow fever.

Inactivated vaccines use a pathogen that has been killed in the laboratory and include vaccines against Hepatitis A, polio- the Inactivated Polio Vaccine or IPV, and Influenza- the inactivated influenza vaccine.

Subunit vaccines contain just a portion of the pathogens- like polysaccharides or proteins and this is done in vaccines against Haemophilus influenzae type B, Hepatitis B, human papillomavirus or HPV, Bordetella pertussis, Streptococcus pneumoniae, Neisseria meningitidis, and varicella zoster virus.



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