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Valvular heart disease: Pathology review




Cardiovascular system

Vascular disorders
Congenital heart defects
Cardiac arrhythmias
Valvular disorders
Heart failure
Cardiac infections
Pericardial disorders
Cardiac tumors
Cardiovascular system pathology review

Valvular heart disease: Pathology review


1 / 16 complete

USMLE® Step 1 style questions USMLE

16 questions

A 20-year-old man is brought to the emergency department following a syncopal episode during football practice. The patient was running towards the end-zone when he suddenly collapsed. Current temperature is 37.0°C (98.6°F), pulse is 80/min, respirations are 15/min, and blood pressure is 118/85 mmHg. ECG demonstrates downsloping ST segment and T wave inversions in leads I, aVL, V4-V6, as well as prominent Q waves in leads II, III, and aVF. On physical examination, a systolic murmur is appreciated over the lower left sternal border. Which of the following maneuvers will increase the intensity of this murmur? 


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On the Cardiology ward, there are two individuals. One of them is 75 year old Antonia, who’s complaining of chest pain and says she hardly catches her breath after walking. On clinical examination, her pulse feels pretty weak and on auscultation, a systolic murmur is heard. The murmur was louder just after S1 and got quieter and quieter by the end of S2.

The other individual is 38 year old Mark who has a history of rheumatic fever and is complaining of not being able to swallow properly. On clinical examination, his voice sounds raspy and on auscultation, a snap is heard after S2 along with a diastolic rumble. Based on auscultation, both individuals were sent for echocardiography.

Okay, so based on auscultation and symptoms, both individuals seem to have valvular heart disease. Valvular heart disease involves damage or a defect in one or more of the four valves of the heart, so the aortic and mitral valves on the left side of the heart, and the pulmonary and tricuspid valves on the right side of the heart.

Okay, now, before talking specifics about valvular disease, we’ll first talk about rheumatic fever, which can affect multiple valves. Rheumatic fever can develop after streptococcal infection like strep throat, which is caused by Streptococcus pyogenes. This particular group of streptococcus has an antigen that lumps it into a group called “group A”, and they also produce an enzyme called streptolysin, which causes hemolysis. Some of these strep bacteria have a protein on their cell wall called “M protein”, and this particular protein is highly antigenic, meaning that the immune system sees it and recognizes it as a foreign molecule and produces antibodies against it.

Now, this becomes a problem when these antigens cause a phenomenon called molecular mimicry. M proteins can be structurally similar to human proteins, which means the antibodies that target them will also target our own tissue. In this case, they are similar to proteins found in the myocardium and heart valves. Once bound to cardiac tissue, the antibodies activate nearby immune cells, which causes a cytokine-mediated inflammatory response and tissue destruction. This is also an example of what’s called a type 2 hypersensitivity reaction.

All right, so not everyone that gets strep throat gets rheumatic fever, and it’s actually only a small minority that get it. However, the individuals that do get rheumatic fever from strep infections will have a variety of clinical findings. These make up the Jones criteria which is divided into 5 major criteria that you have to remember, and 5 minor criteria that are also good to keep in mind. Let’s go over the major criteria first.

The most common is migratory polyarthritis of the joints, where multiple large joints become inflamed, swollen and painful, then the inflammation resolves and spreads to other joints. Secondly, some patients have carditis. The inflammation can affect the endo, myo, and pericardium. Since the endocardium includes the valves, they too are affected.

A high yield fact to remember is that the mitral valve is most commonly affected, although the aortic and tricuspid valve can also be affected. In the acute phase of the illness, mitral regurgitation is most common. Later on, fibrosis around the valve causes its leaflets to fuse together, giving it a fish-mouth-like appearance. This fusion narrows the valve opening, and so we get mitral stenosis.

Now, although not a part of the Jones criteria, a high yield fact is that in histology, there will be Aschoff bodies in the heart. These are granulomas with giant cells consisting of areas of fibrinoid necrosis and lymphocytic infiltration. Within Aschoff bodies, there are characteristic Anitschkow cells which are enlarged macrophages that have a characteristic caterpillar-looking nucleus.

Now for the rest of the Jones criteria, the hypersensitivity reaction in rheumatic fever can affect the skin. So the next criteria is subcutaneous nodules, which are these firm lumps under the skin made up of collagen. The fourth is erythema marginatum, a reddish rash that shows up as rings on the arms or trunk. And finally, there’s Sydenham’s chorea, which is a set of rapid movements of the face and the arms, caused by an autoimmune reaction against the basal ganglia of the brain.

For the minor criteria, there’s polyarthralgia, fever greater or equal to 38.5 degrees celsius, blood tests showing an ESR greater or equal to 60 mm/h, or a CRP greater or equal to 3 mg/dl, prolonged P-R interval, and a blood test that shows evidence of previous streptococcal infection, such as high titers of anti-streptolysin-O, or ASO. Treatment and prophylaxis of rheumatic fever is done using penicillin.

Okay, now let’s look at the specific valvular heart diseases. They can be divided into stenosis, where there’s narrowing of the valvular orifice that prevents adequate outflow of blood, and insufficiency or regurgitation, where the valvular leaflets fail to close correctly and are unable to prevent backflow of blood.

In order to make things easier to remember, we’ll classify valvular disease based on what type of murmurs you hear on auscultation. Remember there are two normal heart sounds; S1, caused by the mitral and tricuspid valves closing at the beginning of systole, and S2, caused by the aortic and pulmonary valves closing at the beginning of diastole.

So first, there are systolic murmurs, which you can hear right after S1 and these happen with aortic stenosis, mitral and tricuspid valve regurgitation. Then there are diastolic murmurs, which come right after S2 and these happen with aortic regurgitation and mitral stenosis.

Let’s start with systolic murmurs and look at aortic stenosis. The aortic valve is typically made up of three leaflets: the right, left, and posterior leaflet and it opens during systole to allow blood to be ejected to the body. During diastole, it closes to allow the heart to fill with blood and get ready for the next systole. Aortic stenosis is when the aortic valve doesn’t open all the way and it gets harder to pump blood into the aorta.

Aortic stenosis is usually caused by chronic mechanical stress that damages endothelial cells around the valves, causing fibrosis and calcification, which hardens the valve and makes it more difficult to open completely. This type usually shows up in late adulthood, so for your exams, remember that this is more common in individuals over 60 years old. Now, if there’s aortic stenosis in a younger individual, the cause could be due to a bicuspid valve. These abnormal valves are more at risk of fibrosis and calcification since the mechanical stress is now being split by just two leaflets.

Okay, let’s go over