Warthin tumor


00:00 / 00:00



Warthin tumor

Eyes, ears, nose and throat

Eye disorders

Color blindness

Cortical blindness


Homonymous hemianopsia

Bitemporal hemianopsia



Retinal detachment

Age-related macular degeneration

Diabetic retinopathy

Corneal ulcer


Retinopathy of prematurity

Periorbital cellulitis



Orbital cellulitis

Hordeolum (stye)


Neonatal conjunctivitis

Ear disorders

Conductive hearing loss

Eustachian tube dysfunction

Tympanic membrane perforation

Otitis externa

Otitis media

Vestibular disorders


Meniere disease


Acoustic neuroma (schwannoma)

Nasal and nasopharyngeal disorders

Choanal atresia

Allergic rhinitis

Nasal polyps

Nasopharyngeal carcinoma

Oral cavity and oropharyngeal disorders



Ludwig angina

Aphthous ulcers

Temporomandibular joint dysfunction

Oral cancer

Warthin tumor

Sleep apnea

Gastroesophageal reflux disease (GERD)

Zenker diverticulum

Retropharyngeal and peritonsillar abscesses

Esophageal cancer

Laryngeal disorders



Bacterial epiglottitis

Thyroid and parathyroid gland disorders

Thyroglossal duct cyst

Thyroid cancer



Eyes, ears, nose and throat pathology review

Eye conditions: Refractive errors, lens disorders and glaucoma: Pathology review

Eye conditions: Retinal disorders: Pathology review

Eye conditions: Inflammation, infections and trauma: Pathology review

Vertigo: Pathology review

Nasal, oral and pharyngeal diseases: Pathology review

Thyroid nodules and thyroid cancer: Pathology review

Parathyroid disorders and calcium imbalance: Pathology review


Warthin tumor


0 / 6 complete

High Yield Notes

18 pages


Warthin tumor

of complete

External Links


Content Reviewers

Rishi Desai, MD, MPH


Tanner Marshall, MS

Warthin’s tumor, or Warthin tumor, is a benign slow-growing tumor of the parotid gland named for Dr. Aldred Scott Warthin, who was the first pathologist to described it.

Normally, the parotid gland has glandular cells that make enzymes that help to break down food, as well as tiny ducts lined by epithelial cells that carry those enzymes towards the mouth.

Warthin tumor’s other name, papillary cystadenoma lymphomatosum, is long and technical but describes the disease pretty well.

Cystadenoma refers to the fact that the ducts grow in size and fill up with serous fluid and cellular debris which forms a large cyst.

Papillary refers to the fact that the layer of epithelial cells start to fold into the duct which forms a finger-like projection, called a papilla.

Finally, lymphomatosum refers to the fact that the epithelium layer gets infiltrated by lymphocytes which organize themselves into what look like germinal centers, which is something you’d would expect to find if you looked at the cross section of a lymph node.

Looking at histology, we can see the papilla, the lymphocytes, and the cystic space where the serous fluid and cellular debris are.

Now, Warthin’s tumor isn’t malignant, meaning that it doesn’t break through the basement membrane layer of the tissue, although there is a connective tissue capsule usually forms around the growing tumor, which clearly demarcates it from the rest of the parotid gland.

Also, the parotid gland start to not function normally, since the ducts turn into cysts and normal epithelial cells stop functioning.


Warthin tumor, also known as papillary cystadenoma lymphomatosum, is a benign tumor that most commonly occurs in the parotid gland, a salivary gland located in the cheek. It is characterized by a cystic structure lined by tall columnar epithelium with lymphoid stroma, and typically presents as a slow-growing, painless mass. Treatment is generally surgical removal of the tumor, and the prognosis is excellent as the tumor is typically benign and does not tend to recur after removal.


  1. "Robbins Basic Pathology" Elsevier (2017)
  2. "Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2)" McGraw-Hill Education / Medical (2018)
  3. "Pathophysiology of Disease: An Introduction to Clinical Medicine 8E" McGraw-Hill Education / Medical (2018)
  4. "CURRENT Medical Diagnosis and Treatment 2020" McGraw-Hill Education / Medical (2019)
  5. "Benign Parotid Tumors" Otolaryngologic Clinics of North America (2016)

Copyright © 2023 Elsevier, except certain content provided by third parties

Cookies are used by this site.

USMLE® is a joint program of the Federation of State Medical Boards (FSMB) and the National Board of Medical Examiners (NBME). COMLEX-USA® is a registered trademark of The National Board of Osteopathic Medical Examiners, Inc. NCLEX-RN® is a registered trademark of the National Council of State Boards of Nursing, Inc. Test names and other trademarks are the property of the respective trademark holders. None of the trademark holders are endorsed by nor affiliated with Osmosis or this website.