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Eyes, ears, nose and throat
Age-related macular degeneration
Retinopathy of prematurity
Conductive hearing loss
Eustachian tube dysfunction
Tympanic membrane perforation
Acoustic neuroma (schwannoma)
Temporomandibular joint dysfunction
Gastroesophageal reflux disease (GERD)
Retropharyngeal and peritonsillar abscesses
Thyroglossal duct cyst
Eye conditions: Refractive errors, lens disorders and glaucoma: Pathology review
Eye conditions: Retinal disorders: Pathology review
Eye conditions: Inflammation, infections and trauma: Pathology review
Vertigo: Pathology review
Nasal, oral and pharyngeal diseases: Pathology review
Thyroid nodules and thyroid cancer: Pathology review
Parathyroid disorders and calcium imbalance: Pathology review
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Tanner Marshall, MS
Warthin’s tumor, or Warthin tumor, is a benign slow-growing tumor of the parotid gland named for Dr. Aldred Scott Warthin, who was the first pathologist to described it.
Normally, the parotid gland has glandular cells that make enzymes that help to break down food, as well as tiny ducts lined by epithelial cells that carry those enzymes towards the mouth.
Warthin tumor’s other name, papillary cystadenoma lymphomatosum, is long and technical but describes the disease pretty well.
Cystadenoma refers to the fact that the ducts grow in size and fill up with serous fluid and cellular debris which forms a large cyst.
Papillary refers to the fact that the layer of epithelial cells start to fold into the duct which forms a finger-like projection, called a papilla.
Finally, lymphomatosum refers to the fact that the epithelium layer gets infiltrated by lymphocytes which organize themselves into what look like germinal centers, which is something you’d would expect to find if you looked at the cross section of a lymph node.
Looking at histology, we can see the papilla, the lymphocytes, and the cystic space where the serous fluid and cellular debris are.
Now, Warthin’s tumor isn’t malignant, meaning that it doesn’t break through the basement membrane layer of the tissue, although there is a connective tissue capsule usually forms around the growing tumor, which clearly demarcates it from the rest of the parotid gland.
Also, the parotid gland start to not function normally, since the ducts turn into cysts and normal epithelial cells stop functioning.
Warthin tumor, also known as papillary cystadenoma lymphomatosum, is a benign tumor that most commonly occurs in the parotid gland, a salivary gland located in the cheek. It is characterized by a cystic structure lined by tall columnar epithelium with lymphoid stroma, and typically presents as a slow-growing, painless mass. Treatment is generally surgical removal of the tumor, and the prognosis is excellent as the tumor is typically benign and does not tend to recur after removal.
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