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Wernicke-Korsakoff syndrome



Nervous system


Central nervous system disorders
Central and peripheral nervous system disorders
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Autonomic nervous system disorders
Nervous system pathology review

Wernicke-Korsakoff syndrome


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Wernicke-Korsakoff syndrome

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Wernicke Korsakoff syndrome is named after Carl Wernicke and Sergei Korsakoff, the physicians who discovered the condition in the late 1800s.

Wernicke Korsakoff syndrome is caused by Vitamin B1 or thiamine deficiency and it refers to a spectrum of disease.

Wernicke's encephalopathy is the acute, reversible stage of the syndrome, and if left untreated it can later lead to Korsakoff syndrome, which is chronic and irreversible.

Thiamine is typically stored in the liver and absorbed in the duodenum and then moves throughout the body, where it’s involved in numerous cellular processes that require thiamine.

The enzyme thiamine pyrophosphate synthetase transfers a pyrophosphate group from ATP to thiamine, turning it into the coenzyme thiamine pyrophosphate - which is the metabolically active form of thiamine.

Now, as a coenzyme, thiamine pyrophosphate functions to assist other enzymes such as pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, and transketolase carry out reactions, particularly regarding glucose metabolism.

Furthermore, within the brain, thiamine pyrophosphate helps metabolize lipids and carbohydrates as well as maintain normal amino acid and neurotransmitter levels.

In some neurons, thiamine even helps with propagation of a neural impulses down the axon.

Given it’s multifaceted role, a deficiency of thiamine can have serious consequences.

Specifically, thiamine deficiency impairs glucose metabolism and this leads to a decrease in cellular energy.

One of the major causes of thiamine deficiency, and therefore Wernicke Korsakoff syndrome, is alcohol abuse.

Alcohol leads to decreased thiamine levels in various ways. First, alcohol interferes with the conversion of thiamine to its active form, thiamine pyrophosphate by blocking the phosphorylation of thiamine.

Second, thiamine is normally absorbed through the first portion of the small intestine called the duodenum.

However, ethanol prevents this absorption process, and it is believed that alcohol does this by reducing the gene expression for thiamine transporter-1 within the intestinal brush border.

Third, chronic alcohol abuse can lead to fatty liver or cirrhosis which interferes with the storage of thiamine within the liver.

Other causes of thiamine deficiency are inadequate intake like in malnutrition and anorexia or due to malabsorption like in stomach cancer and inflammatory bowel disease.

The brain is particularly vulnerable to impaired glucose metabolism since it utilizes so much energy.

Early on in thiamine deficiency, the cerebellum gets affected and that can affect movement and balance.

Wernicke–Korsakoff syndrome is the combined diagnosis of Wernicke's encephalopathy and Korsakoff's syndrome, commonly caused by vitamin B1 (thiamine) deficiency, which is usually secondary to alcohol abuse. It presents with a classic triad of confusion, ophthalmoplegia, and ataxia.
  1. "Robbins Basic Pathology" Elsevier (2017)
  2. "Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2)" McGraw-Hill Education / Medical (2018)
  3. "Pathophysiology of Disease: An Introduction to Clinical Medicine 8E" McGraw-Hill Education / Medical (2018)
  5. "Health problems and care needs in patients with Korsakoff’s syndrome: A systematic review" Journal of Psychiatric and Mental Health Nursing (2020)