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Whipple's disease

Summary of Whipple's disease
Whipple's disease is a rare, systemic infectious disease caused by the bacterium Tropheryma whipplei. Whipple's disease primarily causes malabsorption but may affect any part of the body. Weight loss, diarrhea, joint pain, and arthritis are common presenting symptoms. Whipple's disease is significantly more common in men. Whipple's disease can usually be cured with long-term antibiotic therapy; untreated, the disease is ultimately fatal.




Gastrointestinal system

Peritoneum and peritoneal cavity disorders
Upper gastrointestinal tract disorders
Lower gastrointestinal tract disorders
Liver, gallbladder and pancreas disorders
Gastrointestinal system pathology review

Whipple's disease


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High Yield Notes
7 pages

Whipple's disease

6 flashcards

Whipple disease is treated with therapy.


USMLE® Step 1 style questions USMLE

2 questions

USMLE® Step 2 style questions USMLE

1 questions

A 52-year-old man comes to the office because of pain in his wrists and knees. He is a farmer and initially thought that these symptoms were related to the strain of his work. However, NSAID treatment had led to minimal improvement and he is worried because he has also developed watery diarrhea with cramping for the past three weeks. His pants have felt loose, he says. Biopsy from his small intestine shows PAS-positive macrophages in the lamina propria. Which of the following is the most appropriate initial treatment?   

External References