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Whipple's disease

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Gastrointestinal system

Pathology

Peritoneum and peritoneal cavity
Upper gastrointestinal tract disorders
Lower gastrointestinal tract disorders
Liver, gallbladder and pancreas disorders
Gastrointestinal system pathology review

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Whipple's disease

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High Yield Notes
7 pages
Flashcards

Whipple's disease

6 flashcards
Questions

USMLE® Step 1 style questions USMLE

2 questions
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A 52-year-old man comes to the physician for evaluation of severe pain affecting several joints. The symptoms began 3 months ago. He has also had loose, greasy stools several times daily as well as a 12-lb weight loss. Past medical history is noncontributory. He is not sexually active and does not consume alcohol or illicit substances. Temperature is 37.0°C (98.6°F), pulse is 82/min, respirations are 14/min, and blood pressure is 130/62 mmHg. Cardiac auscultation reveals a soft, high-pitched, early diastolic decrescendo murmur heard best at the left 3rd intercostal space. The left and right knee are warm and tender to palpation, and passive range of motion is limited bilaterally. Abdominal examination reveals intense epigastric pain on palpation. Generalized lymphadenopathy is present. Biopsy of the small intestine reveals periodic acid-Schiff-positive (PAS)-positive macrophages within the lamina propria. Which of the following is the most likely cause of this patient’s underlying condition?  

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Summary
Whipple's disease is a rare, systemic infectious disease caused by the bacterium Tropheryma whipplei. Whipple's disease primarily causes malabsorption but may affect any part of the body. Weight loss, diarrhea, joint pain, and arthritis are common presenting symptoms. Whipple's disease is significantly more common in men. Whipple's disease can usually be cured with long-term antibiotic therapy; untreated, the disease is ultimately fatal.