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Whipple's disease

Summary of Whipple's disease
Whipple's disease is a rare, systemic infectious disease caused by the bacterium Tropheryma whipplei. Whipple's disease primarily causes malabsorption but may affect any part of the body. Weight loss, diarrhea, joint pain, and arthritis are common presenting symptoms. Whipple's disease is significantly more common in men. Whipple's disease can usually be cured with long-term antibiotic therapy; untreated, the disease is ultimately fatal.



Gastrointestinal system


Peritoneum and peritoneal cavity
Upper gastrointestinal tract disorders
Lower gastrointestinal tract disorders
Liver, gallbladder and pancreas disorders
Gastrointestinal system pathology review

Whipple's disease


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High Yield Notes
7 pages

Whipple's disease

6 flashcards

USMLE® Step 1 style questions USMLE

1 questions

A 44-year-old man is referred to a gastroenterologist because of a 6-month history of weight loss, foul-smelling diarrhea, and joint pain. The patient reports that he also occasionally experiences fever and cramping, both relived by non-steroidal anti-inflammatory drugs. The patient does not recall any inciting factors, and has been in good health up to that point. The patient's primary care physician ruled out malignancies, rheumatic disease, and HIV. The patient however tested positive for HLA-B27. A small bowel biopsy with results are shown in the slide below. What of the following findings is most likely associated with the patient's condition?

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