Assessment of X-linked agammaglobulinemia: Video & Anatomy | Osmosis

Question

A 2 year-old boy is brought to the emergency department for evaluation of fever, cough, and shortness of breath. The patient has a history of recurrent infections including otitis media, pneumonia, and erysipelas. He recently recovered from a prolonged course of diarrhea due to infection with Giardia. Temperature is 38.7 C&#176; (101.7 F&#176;), pulse is 140/min, respirations are 55/min and blood pressure is 100/50 mmHg. Physical examination shows small bilateral tonsils and rales in the right lower lobe of the lung. The patient is at 25th percentile for height and 10th percentile for weight. Intraepidermal injection of Candida antigens results in the appearance of a large indurated nodule within 48 hours. Flow cytometry of the patient&#8217;s peripheral blood smear demonstrates absence of CD19+ cells. Impairment of which of the following immunoprotective mechanisms is most likely contributing to this patient&#8217;s disease process?&#160;

Accepted Answer

Antibody production

Answer

Complement production

Answer

Interferon signaling

Answer

Isotype switching

Answer

Leukocyte adhesion

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X-linked agammaglobulinemia

Pathology

Immune system

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X-linked agammaglobulinemia

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AssessmentsX-linked agammaglobulinemia

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X-linked agammaglobulinemia