USMLE® Step 1 style questions USMLE
USMLE® Step 2 style questions USMLE
A 35-year-old woman comes to the office because of an itchy rash on her wrist. She says that it started four days ago and the itching is worsening. Physical examination shows several small, violet papules located on the anterior wrists. Which of the following findings is most likely to be seen in this patient?
Contributors:Evan Debevec-McKenney, Sam Gillespie, BSc, Ahmed A. Abu Ajeene, Ursula Florjanczyk, MScBMC
Lichen planus is an immune-mediated disorder, meaning that the immune system has started attacking its own skin, resulting in a skin rash.
Lichen planus can also affect mucous membrane.
The epidermis forms the thin outermost layer of skin.
Underneath, is the thicker dermis layer that contains the nerves and blood vessels.
And finally, there’s the hypodermis which is made of fat and connective tissue that anchors the skin to the underlying muscle.
The epidermis itself is made of multiple layers of developing keratinocytes - which are flat pancake-shaped cells that are named for the keratin protein that they’re filled with.
Keratinocytes start their life at the lowest layer of the epidermis called the stratum basale, or basal layer, which is made of a single layer of stem cells that continually divide and produce new keratinocytes.
These new keratinocytes then migrate upwards to form the other layers of the epidermis.
The stratum basale also contains another group of cells - melanocytes, which secrete a protein pigment, or coloring substance, called melanin.
As keratinocytes in the stratum basale mature and lose the ability to divide, they migrate into the next layer, called the stratum spinosum which is about 8 to 10 cell layers thick.
The next layer up is the stratum granulosum which is 3 to 5 cell layers thick. Keratinocytes in this layer begin the process of keratinization, which is the process where the keratinocytes flatten out and die.
Keratinization leads to development of the stratum lucidum layer which is 2 to 3 cell layers thick of translucent, dead keratinocytes.
Finally, there’s the stratum corneum, or the uppermost and thickest layer of the epidermis, which is like a wall of 20-30 layers, where the glycolipid acts like the cement and the dead keratinized cells are the bricks.
Now, the part of skin connecting the stratum basale of the epidermis to the underlying dermis is called the dermo-epidermal junction.
In healthy people, this junction looks like smooth waves between the epidermis and the dermis. But, if you look closely at this junction, there are two parts.
The first part is the lower portion of the plasma membrane of the keratinocytes in the stratum basale, which contains glue-like substances called hemidesmosomes.
These hemidesmosomes adhere keratinocytes of the stratum basale to the second component of this junction, which is called the basal lamina.
The basal lamina contains a group of molecules that provide structural and biochemical support to the keratinocytes.
If this were to happen, then a specific cell of the immune system called cytotoxic T cell would use its receptor to bind to the MHC class I molecule, which would cause it to release its payload of perforin and granzymes.
Perforin would perforate the target cell by forming pores, and these pores would allow the granzymes to enter into the cell. Once inside, the granzymes would induce apoptosis, or programmed cell death.
In lichen planus, some healthy non-infected keratinocytes start presenting antigens on MHC I molecules, and it’s unclear why they do that.
This antigen presentation on MHC I molecules enables cytotoxic T cells to attack these keratinocytes and kill them.
In killing the keratinocytes, these cytotoxic T cells also release cytokines, which recruit more cytotoxic T cells to the scene. That leads to more damage to the keratinocytes, as well as the surrounding tissue in the basal lamina.
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