Renal cancer Notes
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This Osmosis High-Yield Note provides an overview of Renal cancer essentials. All Osmosis Notes are clearly laid-out and contain striking images, tables, and diagrams to help visual learners understand complex topics quickly and efficiently. Find more information about Renal cancer:
NOTES NOTES RENAL CANCER GENERALLY, WHAT IS IT? PATHOLOGY & CAUSES ▪ Abnormal cell growth → kidney mass (malignant/benign), caused by genetic mutation of tumor suppressor gene ▪ Angiomyolipoma: most common benign renal tumor ▪ Renal cell carcinoma: most common malignant renal tumor in adults ▪ Wilms tumor: most common malignant renal tumor in children COMPLICATIONS ▪ Spontaneous hemorrhage, kidney highly vascular ▪ Malignant ▫ Distant metastasis SIGNS & SYMPTOMS ▪ Often asymptomatic initially ▪ Unilateral abdominal mass ▪ Flank pain, hematuria, systemic symptoms (e.g. fever, appetite loss) ▪ Ectopic hormone production: renin, erythropoietin (EPO), adrenocorticotropic hormone (ACTH), parathyroid hormonerelated peptide (PTHrP) → paraneoplastic syndromes 844 OSMOSIS.ORG DIAGNOSIS DIAGNOSTIC IMAGING CT scan/MRI/ultrasound ▪ See individual disorders LAB RESULTS ▪ Tissue biopsy TREATMENT MEDICATIONS ▪ Malignant: chemotherapy SURGERY ▪ Malignant: surgical resection OTHER INTERVENTIONS ▪ Angiomyolipoma: embolization, surgery not suitable ▪ Malignant: radiotherapy
Chapter 119 Renal Cancer ANGIOMYOLIPOMA osms.it/angiomyolipoma PATHOLOGY & CAUSES ▪ Most common benign kidney tumor ▪ Also found in liver (common), reproductive organs (rare) ▪ Made of blood vessels (angio), smooth muscle (myo), fat (lipo) ▪ Type of hamartoma: cellular tumor, disorganized architecture ▪ Genetic mutation in tumor suppressor gene tuberous sclerosis 1 (TSC1) for hamartin/ tuberous sclerosis 2 (TSC2) for tuberin ▫ Usually sporadic ▫ Associated with tuberous sclerosis (multiple, bilateral angiomyolipomas) ▪ Perivascular epithelioid cell tumor family (PEComa): epithelial-like cells around blood vessels on microscopy ▪ More common in right kidney RISK FACTORS ▪ Individuals who are biologically female ▪ Tuberous sclerosis COMPLICATIONS ▪ Spontaneous hemorrhage risk ▫ Dysregulated angiogenesis → weak blood vessels → aneurysms SIGNS & SYMPTOMS ▪ Small: often asymptomatic ▪ Large: mass effect on healthy kidney tissue → chronic kidney disease ▪ Extreme cases: end-stage renal disease (dialysis needed) DIAGNOSIS DIAGNOSTIC IMAGING Ultrasound ▪ Fat appears hyperechogenic MRI ▪ Small lesions with wedge-shaped pattern which grow outward as tumor enlarges; fat appears bright on T1-weighted images, intermediate-dark on T2-weighted images Figure 119.1 Histological appearance of an angiomyolipoma. The tumor is composed primarily of myoid cells with areas of mature adipose tissue and numerous vessels. LAB RESULTS ▪ Image-guided percutaneous needle biopsy and histological analysis OSMOSIS.ORG 845
TREATMENT ▪ Surgery unlikely to be useful, highly vascular tumors with high bleeding risk OTHER INTERVENTIONS Embolization ▪ Synthetic emboli released into tumor vessels → vessel occlusion → tumor necrosis → tumor shrinkage, haemorrhage less likely ▪ Adverse effects ▫ Postembolization syndrome, fever, ﬂank pain, malaise Figure 119.2 An abdominal CT scan in the axial plane demonstrating an angiomyolipoma of the left kidney. RENAL CELL CARCINOMA (RCC) osms.it/renal-cell-carcinoma PATHOLOGY & CAUSES ▪ Most common malignant kidney tumor in adults ▪ “Silent cancer,” may be asymptomatic until late stage, poor prognosis ▪ Spontaneous: solitary upper pole tumors ▪ Inherited: young adults; multiple, bilateral tumors ▫ Von Hippel–Lindau (VHL) disease: inherited RCC TYPES Clear cell carcinoma ▪ Epithelial cells in proximal convoluted tubule in renal cortex ▫ Polygonal epithelial cells: clear cytoplasm, full of carbohydrate, fat ▫ Fat in tumor cells → yellow tumor Papillary carcinoma Chromophobe carcinoma 846 OSMOSIS.ORG RISK FACTORS Individuals who are biologically male Advanced age Lifestyle factors (e.g. smoking, obesity) Hypertension Environmental exposures (e.g. asbestos, heavy metals) ▪ Existing kidney disease ▫ Acquired renal cystic disease, long-term dialysis, renal transplant ▪ Genetic mutations in chromosome 3p common in spontaneous, inherited ▪ ▪ ▪ ▪ ▪ STAGING ▪ Tumor, nodes, metastasis (TNM), scored 0–4 ▫ T: size, sites invaded (e.g. renal vein) ▫ N: degree of spread to retroperitoneal lymph nodes ▫ M: presence of distant metastasis
Chapter 119 Renal Cancer SIGNS & SYMPTOMS Flank pain Hematuria Palpable mass in abdomen/lower back Systemic symptoms (e.g. fever, weight loss, night sweats, weakness, malaise) ▪ Ectopic hormone secretion → paraneoplastic syndromes ▫ Erythropoietin: polycythemia → hyperviscosity symptoms ▫ Renin: hypertension ▫ PTHrP → hypercalcemia ▫ ACTH → cortisol release → Cushing syndrome ▪ Left varicocele (testicular swelling) ▫ RCC in left kidney → obstructs left renal vein → drains left testicular vein ▪ Lung/bone presentations ▫ RCC invades renal vein/inferior vena cava (IVC) → quick metastasis ▪ ▪ ▪ ▪ SURGERY Resection ▪ If localized Figure 119.3 Histological appearance of renal cell carcinoma. The tumor is of the clear cell subtype. DIAGNOSIS DIAGNOSTIC IMAGING ▪ Some of newly diagnosed individuals ▫ Metastases on radiology, esp. lungs/ bones CT scan of chest/abdomen with contrast ▪ CT scan chest to evaluate metastasis Ultrasound TREATMENT Figure 119.4 A CT scan in the axial plane demonstrating a renal cell carcinoma (RCC) of the left kidney. ▪ Chemotherapy/radiotherapy resistant MEDICATIONS ▪ Immunomodulatory drugs ▫ Activate immune system to attack tumor; interferon, interleukin-2 (IL-2), monoclonal antibodies (nivolumab) ▪ Molecular targeted drugs ▫ Inhibit growth receptors; everolimus, temsirolimus OSMOSIS.ORG 847
Figure 119.5 Histological appearance of a papillary renal cell carcinoma. The tumor is composed of numerous clusters of malignant cells arranged around ﬁbrovascular cores. WAGR SYNDROME osms.it/WAGR-syndrome PATHOLOGY & CAUSES ▪ Genetic disorder affecting children predisposed to Wilms tumor ▫ Wilms’ tumor ▫ Aniridia (total/partial absence of iris) ▫ Genitourinary anomalies ▫ Intellectual disability (previously mental Retardation) ▪ Sporadic mutation → autosomal dominant inheritance TYPES WAGRO (O for obesity) subtype ▪ Additional deletion of brain-derived neurotrophic factor (BDNF) gene → obesity 848 OSMOSIS.ORG CAUSES Contiguous gene deletion syndrome ▪ Heterozygous deletion of several genes beside each other on p arm of chromosome 11 ▫ Deletion of WT1 → Wilms’ tumor, genitourinary malformations ▫ Deletion of PAX6 protein → aniridia ▫ Genetic basis for intellectual disability unclear COMPLICATIONS ▪ Streak ovaries in individuals who are biologically female; gonadoblastoma
Chapter 119 Renal Cancer TREATMENT SIGNS & SYMPTOMS ▪ Few patients with WAGR exhibit all symptoms ▪ Wilms’ tumor (nephroblastoma) ▫ Only ⅓ of individuals with WAGR ▪ Aniridia (since birth) ▫ Most common feature ▫ Blurry vision, photophobia ▪ Genitourinary anomalies ▫ In individuals who are biologically male: cryptorchidism (undescended testes), hypospadias (urethra opens onto underside of penis, not tip) ▫ In individuals who are biologically female: streak ovaries (undeveloped ovaries; increased risk of gonadoblastoma) ▫ Ambiguous genitalia ▪ Intellectual disability ▫ Not always present, often associated with autism/attention deﬁcit hyperactivity disorder (ADHD) ▪ Other features ▫ Progressive kidney failure ▫ Growth retardation, small head size, obesity ▫ Cataracts, glaucoma, nystagmus ▪ Each symptom addressed independently MEDICATIONS Chemotherapy ▪ Wilms’ tumor SURGERY Nephrectomy ▪ Wilms’ tumor OTHER INTERVENTIONS Radiotherapy ▪ Wilms’ tumor Tinted lenses ▪ Photophobia from aniridia Medical surveillance ▪ Wilms’ tumor ▫ Renal ultrasound, blood pressure ▪ Genitourinary ▫ Pelvic US for gonadoblastoma in individuals who are biologically female DIAGNOSIS LAB RESULTS Fluorescence in situ hybridization (FISH) ▪ DNA mixed with ﬂuorescently-labeled DNA probe ▪ Genetic deletion on one chromosome → only one bright spot OSMOSIS.ORG 849
WILMS' TUMOR osms.it/wilms-tumor PATHOLOGY & CAUSES ▪ Most common malignant kidney tumor in children, typically ages 2–5 ▪ AKA nephroblastoma (metaphrenic blastemal cells) ▪ Wilms’ tumor typically appears in otherwise healthy children ▫ Beta-catenin mutations in 10% of sporadic Wilms’ tumors ▪ Tumors composed of metanephric blastemal cells ▫ Abortive/partly-developed structures of nephron ▫ Triphasic blastoma: tumor composed of blastemal, stromal, epithelial cells CAUSES Genetic mutations ▪ Chromosome 11, short arm p, region 1, band 3 ▪ Loss-of-function mutation in Wilms’ Tumor 1 (WT1); may be part of wider developmental syndrome with additional abnormalities ▫ WAGR syndrome: genetic disorder affecting children predisposed to Wilms’ tumor ▫ Denys–Drash syndrome: WT1 mutation → Wilms’ tumor, earlyonset nephrotic syndrome, male pseudohermaphroditism ▪ Wilms’ Tumor 2 (WT2) mutation → developmental syndromes (e.g. Beckwith– Wiedemann syndrome) ▪ Majority of cases not associated with WT1/ WT2 mutations, developmental syndromes RISK FACTORS ▪ Ages 2–5 ▪ Developmental syndromes: WAGR, Beckwith–Wiedemann, Denys–Drash ▪ Family history of Wilms’ tumor 850 OSMOSIS.ORG COMPLICATIONS ▪ Distant metastasis to brain, lungs, liver, bones ▪ Paraneoplastic syndrome ▫ Renin secretion → high blood pressure → decreased kidney function SIGNS & SYMPTOMS ▪ Large, palpable, unilateral ﬂank mass (bilateral tumors) ▪ Abdominal pain ▪ Constipation (due to kidney hemihypertrophy) ▪ Hematuria ▪ Systemic symptoms (e.g. loss of appetite, fever, nausea, weakness) ▪ Renin secretion → hypertension Figure 119.6 A CT scan in the axial plane demonstrating a Wilms’ tumor of the right kidney.
Chapter 119 Renal Cancer ▪ Developmental syndromes ▫ Denys–Drash syndrome: Wilms’ tumor, early-onset nephrotic syndrome, male pseudohermaphroditism ▫ Beckwith–Wiedemann syndrome: Wilms’ tumor, macroglossia, organomegaly, hemihypertrophy DIAGNOSIS ▪ Never palpation ▫ Risk of tumor rupture, metastasis Abdominal ultrasound ▪ Presence of mass, renal vein inﬁltration Abdominal contrast-enhanced CT scan/MRI ▪ Tumor staging; lymph node metastasis penetration of capsule Chest CT scan ▪ Detects metastasis LAB RESULTS ▪ Image-guided percutaneous needle biopsy and histologic analysis TREATMENT ▪ Depends on genetic mutations, tumor aggressiveness, unilateral/bilateral MEDICATIONS ▪ Chemotherapy SURGERY ▪ Nephrectomy OTHER INTERVENTIONS ▪ Radiation ▫ Used with care, risk of secondary cancers Figure 119.7 Histological appearance of Wilms’ tumor. The tumor is triphasic, composed of blastema, stroma and immature epithelial elements (glomeruli and tubules). OSMOSIS.ORG 851
Figure 119.9 Illustration of the signs and symptoms of Wilms’ tumor, which most commonly affects children who were otherwise healthy. Figure 119.8 Gross pathological appearance of a nephrectomy specimen in a patient with Wilms’ tumor. 852 OSMOSIS.ORG
Osmosis High-Yield Notes
This Osmosis High-Yield Note provides an overview of Renal cancer essentials. All Osmosis Notes are clearly laid-out and contain striking images, tables, and diagrams to help visual learners understand complex topics quickly and efficiently. Find more information about Renal cancer by visiting the associated Learn Page.