Video - Nephrotic syndromes: Pathology review

Nephrotic syndrome is a kidney disorder characterized by abnormal filtration in the glomeruli, because glomeruli are damaged and are unable to properly retain proteins in the blood. This can lead to protein in the urine, low protein levels in the blood, and swelling.

Nephrotic syndrome is characterized by proteinuria that exceeds 3.5 grams per 24 hours. Loss of such a large amount of proteins leads to swelling (edema) in the legs, ankles, and other parts of the body, as well as an increased risk of infections and blood clots. Nephrotic syndrome can be caused by various conditions, including kidney diseases, diabetes, and lupus. It is usually treated with medications to control the underlying cause.