Acute leukemia Quiz: Ace Your Exams

Get ready to dominate your medical and nursing exams by using our dynamic quizzes to elevate your knowledge and increase your confidence. Whether you're gearing up for the USMLE®, COMLEX®, or your next in-class assessment, Osmosis quizzes tackle key topics in pathology, diagnostics, and treatment approaches. By honing in on clinical readiness and decision-making, we make sure the knowledge you gain empowers you both in the classroom and in real-world practice. Jump in and supercharge your exam prep!

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A 60-year-old man presents to the clinic because of progressive fatigue, fevers, and night sweats for the past 3 months. Past medical history is significant for 3 episodes of sinusitis in the last 6 months, which all resolved with the use of oral antibiotics. Temperature is 38.3°C (101°F), pulse is 105/min, respirations are 20/min, and blood pressure is 135/85 mmHg. Physical examination shows mucosal pallor and purpuric rashes on lower extremities. There is no lymphadenopathy.  
A table shows complete blood count lab values. Hemoglobin is 8.5 g/dL (ref 13.5-17.5). Platelet count is 70,000/mm³ (ref 150,000-400,000). Leukocyte count is 6,000/mm³ (ref 4,500-11,000).

After appropriate workup, bone marrow biopsy reveals myeloblasts, as depicted in the following:  
A microscopy image shows a cluster of large, dark-stained cells, likely white blood cells, against a lighter background. Some smaller, round cells are also visible.
 Reproduced from: Wikimedia Commons  

Which of the following is the most likely diagnosis in this patient?  

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