Amenorrhea Quiz: Ace Your Exams
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A 16-year-old girl comes to the office for the evaluation of absent menses. The patient has not had a menstrual period yet but is otherwise healthy. Past medical history is noncontributory. Vitals are within normal limits. Physical examination shows appropriate breast development and growth of pubic and underarm hair. The patient declined a vaginal exam. Karyotype analysis reveals 46 XX. Pregnancy test is negative; thyroid stimulating hormone, prolactin, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels are normal. Pelvic ultrasound shows 2 normal-sized ovaries but no uterus. Which of the following is the most likely underlying pathophysiology of this patient’s condition?
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