Approach to involuntary movements Quiz: Ace Your Exams

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A 64-year-old man is brought to the neurology clinic by his partner for evaluation of abnormal movements and forgetfulness. Over the last six months, the patient has had progressive forgetfulness, and he has become increasingly irritable. He experiences involuntary quick limb jerks that cause him to drop items. Past medical history is noncontributory, and he takes no medications. Temperature is 37.0°C (98.6°F), pulse is 84/min, respirations are 14/min, and blood pressure is 120/78 mmHg. Examination shows minimal speech or spontaneous movement, intermittent myoclonus, and an ataxic gait. A urine drug test, serum ethanol level, comprehensive metabolic profile, and computerized tomography (CT) of the head are all within normal limits. Which of the following tests will confirm the most likely diagnosis?

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