Autosomal trisomies Quiz: Ace Your Exams

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A 37-year-old woman, gravida 2 para 0, comes to the office for a routine prenatal evaluation. She previously had a regular menstrual period every 28 days and is currently at 17 weeks gestation. Past medical history is significant for a first trimester miscarriage 2 years ago. She regularly takes prenatal vitamins and has no other medical conditions. Vital signs are within normal limits. The uterus is soft and palpable just below the umbilicus. A fetal anomaly scan performed at 13 weeks gestation revealed increased nuchal translucency. A second trimester quadruple screening test is performed at this visit. Results are shown are show below:  
 
 Laboratory value  Result 
 Maternal serum alpha fetoprotein  Low 
 Unconjugated estriol  Low 
 β-HCG  High 
 Inhibin A  High 

Which of the following is the most likely abnormality associated with this finding?

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