Blood transfusion reactions and transplant rejection Quiz: Ace Your Exams
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A 58-year-old individual with a history of chronic kidney disease presents to the physician to discuss the option of kidney transplantation. The patient developed renal failure secondary to glomerulosclerosis 15 years ago. The patient underwent a successful kidney transplantation 10 years ago from a related donor, but the transplant failed and was removed three years ago. The patient is currently on hemodialysis. Past medical history includes hypertension, diabetes mellitus, and a deep venous thrombosis in the left lower extremity, now resolved. After significant deliberation, the patient undergoes a kidney transplantation from a non-related donor. Eight hours after the surgery, the patient develops chills, malaise, and fever. Temperature is 38.5°C (101.3°F), blood pressure is 104/70, and pulse is 102/minute. The patient has not made urine in the past five hours. The surgeon suspects complications with the transplanted organ, and the patient is brought back to the operating room. On open laparotomy, the transplanted kidney appears mottled and cyanotic. Which of the following best describes the pathophysiology of this patient’s condition?
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