Blood transfusion reactions and transplant rejection Quiz: Ace Your Exams
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A 64-year-old individual undergoes further evaluation by a nephrologist after being found to have elevated blood pressure and proteinuria. The patient underwent successful kidney transplantation two years ago and has been taking tacrolimus daily. Past medical history is significant for type II diabetes mellitus complicated with diabetic nephropathy and end-stage renal disease. The patient tells the physician that they are not completely adherent to their medication as they sometimes forget to take it. Temperature is 37°C (98.6°F), pulse is 92/minute, and blood pressure is 160/95 mmHg. The patient has not had hypertension in the past. Laboratory evaluation shows elevated serum creatinine in addition to proteinuria. A biopsy is taken from the transplanted kidney and shows arteriosclerosis of the transplanted organ vessels in addition to parenchymal fibrosis and tubular atrophy. Which of the following is the most likely cause of this patient’s condition?
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