Blood transfusion reactions and transplant rejection Quiz: Ace Your Exams

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A 50-year-old individual presents to the physician for evaluation of persistent diarrhea and a skin rash for the past week. The patient’s diarrhea began one week ago, is watery, and persists even during fasting. Yesterday, the patient noticed blood in the stool as well. In addition, the patient started experiencing a painful rash on their neck, shoulders, and the palms of their hands. The patient was diagnosed with acute leukemia six months ago and received a bone marrow transplantation two months ago after chemotherapy and radiotherapy. Vitals are within normal limits. On physical examination, a maculopapular rash is noted on the shoulders, arms, palms, and soles. Oral examination reveals the presence of mouth ulcers. On laboratory tests, serum alkaline phosphatase and serum bilirubin are elevated. Which of the following is the most likely cause of this patient’s condition?  

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