Congenital neurological disorders Quiz: Ace Your Exams

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A 6-month-old infant boy is brought to the pediatrician by his mother. The patient's mother delivered the child at home and did not receive consistent prenatal care. The patient’s weight and head circumference are <5th percentile. An examination of the head is consistent with microcephaly. He is noted to have severe developmental delay with attainment of few milestones in speech, gross motor, and fine motor development. The infant cannot roll over or lift his head. An MRI of the brain is obtained and shown below:  

A brain M R I shows a horizontal view of a human head. The brain tissue has an abnormal, wavy appearance w/ thick folds & shallow grooves. An arrow points to the outer brain layer.
Retrieved from: Wikipedia  

Which of the following is the most likely diagnosis?   

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