Diabetes insipidus Quiz: Ace Your Exams

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A 56-year-old man is found unconscious in his apartment by a neighbor who calls emergency services. Upon arrival at the emergency department (ED), the patient is confused and somnolent. The patient’s full medical history is not known, but the neighbor states that the patient has a history of psychiatric illness. Temperature is 37.0 ℃ (98.6 ℉), heart rate is 116/min, respiratory rate is 14/min, blood pressure is 98/60 mmHg, and oxygen saturation is 97% on room air. On examination, dry mucous membranes and significantly decreased skin turgor are noted. Cardiopulmonary and abdominal examinations are unremarkable. Neurologic examination is nonfocal. A urinary catheter is placed and a large amount of clear yellow urine is evacuated. Initial laboratory tests are listed below. The ED physician initiates fluid resuscitation and insulin therapy for a suspected diagnosis of hyperosmolar hyperglycemic state. Which of the following is most likely the correct diagnosis, and based on that diagnosis, what changes should be made to the initial treatment?

 Laboratory study     Result     Reference range    
 Serum sodium     154 mEq/L     136-146 mEq/L    
 Serum glucose     136 mg/dL     70-110 mg/dL    
 Serum osmolality     320 mOsm/kg     275-295mOsm/kg    
 Serum beta-hydroxybutyrate      <0.05 mmol/L      <0.05 mmol/L    
 Lactic acid     3.1 mmol/L     0.5-2.2 mmol/L    
 Urine osmolality     110 mOsm/kg     50-1,200 mOsm/kg    

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