Disorders of sex chromosomes Quiz: Ace Your Exams

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A 5-month-old female infant is admitted to the pediatric intensive care unit for surgical treatment of preductal coarctation of the aorta. The patient is stable and afebrile. Blood pressure is 70/50 mmHg, and respiratory rate is 34/min. During subsequent evaluation, the patient is found to have a horseshoe kidney as well as lymphedema affecting the hands and feet. The patient has low set ears. Which of the following is the most likely genetic aberration that led to this patient’s presentation?

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Nondisjunction resulting in Trisomy 18

Nondisjunction event during meiosis

Nondisjunction resulting in Trisomy 21

Nondisjunction event during mitosis

Partial loss of chromosome during mitosis