Drug misuse, intoxication and withdrawal Quiz: Ace Your Exams
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A 40-year-old man comes to the emergency department for restlessness and gastrointestinal symptoms for the past 24 hours. The patient reports 3-4 episodes of severe abdominal cramps followed by bouts of diarrhea. Since this morning, he has also had four episodes of vomiting following persistent nausea. Past medical history is significant for polysubstance use and alcohol use disorder. Family history is unremarkable. Temperature is 36.6°C (97.8°F), pulse is 108/min, respirations are 15/min and blood pressure is 157/92 mmHg. Physical examination demonstrates mydriasis, rhinorrhea, yawning, and diaphoresis. Bowel sounds are increased on abdominal auscultation. Methadone is administered to the patient, which results in the resolution of his symptoms. Which of the following best describes the mechanism of action of this medication?
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