Endometrial intraepithelial neoplasia (hyperplasia) and carcinoma Quiz: Ace Your Exams

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A 48-year-old woman presents to the gynecology office with abnormal uterine bleeding. The patient reports heavy bleeding with menstruation, soaking through more than one pad per hour for 10 days. This has been occurring every 4 weeks for the past 6 months. There is no associated fatigue, shortness of breath, or chest pain. Past medical history includes type 2 diabetes, and family history is significant for Lynch syndrome. Vital signs are within normal limits. A chaperoned physical examination reveals a non-tender, enlarged, globular uterus. Transvaginal ultrasound rules out structural causes of abnormal uterine bleeding. Which of the following is the most appropriate diagnostic study to obtain now?

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