Gout Quiz: Ace Your Exams
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A 61-year-old woman comes to the PA complaining of severe pain in the right knee. She reports that it has been painful, warm, and red over the past day. She states that similar symptoms occurred two-years ago in her left toe, which resolved spontaneously without treatment. Past medical history significant for hypertension and hyperlipidemia. Medications include pravastatin and hydrochlorothiazide. Temperature is 37.0°C (98.6°F), pulse is 98/min, respirations are 14/min, and blood pressure is 130/92 mmHg. Physical examination reveals swelling, erythema, and warmth of the right knee joint. It is tender to palpation with decreased active and passive range of motion. Arthrocentesis of the joint yields turbid fluid with a leukocyte count of 19,200/mm3. Gram stain is negative. Polarized light microscopy shows yellow, negatively birefringent crystals. The patient is provided with naproxen for symptomatic treatment. Which of the following best describes the mechanism of this medication?
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