Jaundice Quiz: Ace Your Exams
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A 41-year-old man comes to his primary care PA because of fatigue, jaundice, and pruritus. His symptoms began 1 month ago and have progressively worsened. Past medical history is notable for ulcerative colitis, which was diagnosed seven years ago, and hypertension. Family history is positive for cholecystitis in his older sister. In the office, his temperature is 37.4°C (99.3°F), blood pressure is 147/88 mmHg, and pulse is 74/min. Physical examination shows jaundice, scleral icterus, and hepatomegaly. Laboratory testing reveals the following findings:
Radiographic imaging and biopsy are scheduled as part of the work-up process. Which of the following findings will be most likely found on this patient’s biopsy?
| Laboratory value | Result |
| Total bilirubin | 6.5 mg/dL (reference range: 0.1-1 mg/dL) |
| Conjugated bilirubin | 5.9 mg/dL (reference range: 0.0-0.3 mg/dL) |
| Alanine aminotransferase | 127 U/L (reference range: 8-40 U/L) |
| Aspartate aminotransferase | 115 U/L (reference range 8-40 U/L) |
| Alkaline phosphatase | 142 U/L (reference range: 20-70 U/L) |
Radiographic imaging and biopsy are scheduled as part of the work-up process. Which of the following findings will be most likely found on this patient’s biopsy?
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