Jaundice Quiz: Ace Your Exams

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A 6-day-old female is brought to the pediatrician by her parents for evaluation of jaundice. She was born at 36 weeks gestation to a 29-year-old, gravida 1 para 1, woman via an uncomplicated vaginal delivery. According to her parents, the patient has had difficulty latching to her mother’s breast. The patient has passed meconium and produces 3-4 wet diapers per day. In the office, she is fussy but consolable. Physical examination shows depressed anterior and posterior fontanelles. Scleral icterus and jaundice of the head and chest are observed. Cardiac, pulmonary, and abdominal exams are noncontributory. Which of the following best describes the pathophysiology of this patient’s condition?

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Increased red blood cell turnover

Decreased elimination of bilirubin via feces

Extrahepatic fibrosis of the bile ducts

Increased intestinal deconjugation of bilirubin

Impaired conjugation of bilirubin in the liver