Miscellaneous genetic disorders Quiz: Ace Your Exams

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A 4-year-old girl with severe intellectual disability is brought to the physician for follow-up. The patient is nonverbal, and she did not begin walking until the age of two. Last year, she was initiated on valproate due to recurrent seizures. During the interview, the physician notices that the patient smiles constantly and laughs most of the time. She claps her hands and laughs hysterically without prompting. Family history is negative for neurological disorders. At the end of the interview, the mother asks the physician about the possibility of having additional children with the same condition. Which of the following is the most appropriate response by the physician?

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The probability of having another child with this condition is 50% because it is an autosomal dominant disorder.

The probability of having a child with this condition is related to the gender of the child.

The probability of having a child with this condition is related to maternal age.

Alcohol use during pregnancy is associated with the development of this condition.

This is most likely a non-inherited condition due to random events occurring in the egg or sperm.