Nephrotic syndromes Quiz: Ace Your Exams

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A 52-year-old female comes to the primary care PA due to worsening weight gain. She has gained approximately 20 lbs over the past six weeks. In addition, the patient has been experiencing lower extremity edema and has noticed her urine appears more cloudy than usual. Past medical history is notable for hypertension and hyperlipidemia. Temperature is 37.3°C (99.1°F), pulse is 76/min, respirations are 18/min, blood pressure is 137/84 mmHg, and O2 saturation is 97% on room air. Physical exam is notable for bilateral pitting edema of the lower extremities. A urinalysis is notable for 4+ protein (reference range: none) and oval fat bodies but no hematuria. A renal biopsy is performed, and light microscopy demonstrates diffuse capillary and glomerular basement membrane thickening, as shown below:

A microscopy image shows a renal glomerulus, a small, round cluster of capillaries. It has a complex, tangled appearance.
Reproduced from: Wikipedia

Which of the following is most suggestive of this patient’s underlying diagnosis?

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