Non-hemolytic normocytic anemia Quiz: Ace Your Exams

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A 70-year-old male comes to the clinic complaining of fatigue, dizziness, and shortness of breath. Past medical history includes type II diabetes mellitus and chronic kidney disease, for which he has been on dialysis for the last 4 years. Temperature is 37°C (98.6°F), pulse is 86/min, respirations are 18/min, and blood pressure is 136/78 mmHg. Physical exam shows pallor of the conjunctiva and finger nail beds. Laboratory tests are obtained and the results are shown below.

 Laboratory value  Result  Reference Range 
 Hematologic  
 Hemoglobin  9.5 g/dL  13.5-17.5 g/dL 
 Mean corpuscular volume (MCV)   82 fL  80-100 fL 
 Reticulocyte index  1.6%  0.5-1.5% 
 Platelet count  280,000/mm3   150,000-400,000 
 Leukocyte count   10,000/μL  4,500-11,000/μL 
 Iron studies  
 Serum iron  25 μg/dL  50-170 μg/dL 
 Ferritin  400 ng/mL  15-200 ng/mL 
 Transferrin  150 mg/dL  170-370 mg/dL 
 Total iron binding capacity  210 μg/dL  240-450 μg/dL  

 The patient is provided with a medication that activates the JAK2 signalling cascade on the surface of erythrocyte progenitor cells. Which of the following medications was most likely given? 

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