Parkinson disease Quiz: Ace Your Exams

Get ready to dominate your medical and nursing exams by using our dynamic quizzes to elevate your knowledge and increase your confidence. Whether you're gearing up for the USMLE®, COMLEX®, or your next in-class assessment, Osmosis quizzes tackle key topics in pathology, diagnostics, and treatment approaches. By honing in on clinical readiness and decision-making, we make sure the knowledge you gain empowers you both in the classroom and in real-world practice. Jump in and supercharge your exam prep!

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A 70-year-old man with a history of Parkinson disease comes to the office for follow-up. He was diagnosed 6 years ago, and since then, the condition has been well-controlled with levodopa/carbidopa. However, for the past 2 months, the patient reports increased difficulty ambulating, loss of balance and increased rigidity. He is compliant with the treatment and describes fluctuations in the symptoms that improve after he takes the medication. Physical examination reveals diffuse cogwheel rigidity and difficulty walking. A decision is made to add a medication that will descrease the symptoms between levodopa/carbidopa doses. Which of the following best describes the mechanism of action of this medication?

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Inhibits the conversion of L-dopa to dopamine in the periphery

Increases dopamine release and inhibits its reuptake

Directly activates dopamine receptors

Inhibits the peripheral degradation of L-DOPA to 3-O-methyldopa (3‑OMD) by inhibiting catechol-O-methyltransferase (COMT) enzyme

Inhibits the conversion of dopamine to 3,4-Dihydroxyphenylacetic acid (DOPAC)