Platelet disorders Quiz: Ace Your Exams

Get ready to dominate your medical and nursing exams by using our dynamic quizzes to elevate your knowledge and increase your confidence. Whether you're gearing up for the USMLE®, COMLEX®, or your next in-class assessment, Osmosis quizzes tackle key topics in pathology, diagnostics, and treatment approaches. By honing in on clinical readiness and decision-making, we make sure the knowledge you gain empowers you both in the classroom and in real-world practice. Jump in and supercharge your exam prep!

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An 11-year-old girl is brought to the clinic by her parent due to excessive bleeding with menstruation, lightheadedness, and headaches. The patient states the symptoms started 6 months ago with her first menstrual period. Temperature is 37.1°C (98.8°F), pulse is 81/min, respirations are 12/min, and blood pressure is 112/66 mmHg. Physical exam reveals conjunctival pallor. Laboratory testing is obtained, and the results are shown below.  
 
Laboratory value  Results
 Hematologic  
 Platelet count  180,000/mm3  
 Hemoglobin  9.7 g/dL 
Coagulation studies  
 Prothrombin time (PT)  12 seconds 
 Activated partial thromboplastin time (aPTT)  30 seconds 
 Bleeding time*  12 minutes 
*Reference Range: 2-7 minutes  
 
A sample of the patient’s blood is collected. Administration of risotectin to the sample fails to induce platelet aggregation. Which of the following is the most likely cause of this patient’s condition?   

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