Renal tubular acidosis Quiz: Ace Your Exams

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A 35-year-old woman presents to the emergency department with 3 days of difficulty urinating, right flank pain, malaise, and nausea. Medical history includes chronic migraines for the last 10 years, for which she has been taking ibuprofen multiple times daily. Temperature is 37.0°C (98.6°F), pulse is 90/min, respirations are 22/min, and blood pressure is 112/68 mmHg. Laboratory testing is obtained and the results are shown below.  
 
 Laboratory value  Result  Reference range 
 Arterial blood gas  
 pH  7.2  7.35-7.45 
 pCO2  28 mmHg  33-45 mmHg 
 pO2  80 mmHg  75-105 mmHg 
 Blood, serum, plasma  
 Sodium  138 mEq/L  136-146 mEq/L 
 Chlorine  119 mEq/L  95-105 mEq/L 
 Potassium   3.1 mEq/L  3.5-5 mEq/L 
 Bicarbonate  14 mEq/L  22-28 mEq/L 
 Urine  
 pH  8.1  4.6-8 
   
Which of the following is the most likely cause of this patient’s symptoms? 

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