Systemic sclerosis (scleroderma) Quiz: Ace Your Exams
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A 46-year-old woman presents to the clinic with several months of skin tightening over her hands and arms. Four months ago, she had puffy swollen hands and then started developing skin tightening. She also experiences numbness and changes in the color of her fingers in cold weather. She has had increasing fatigue and shortness of breath, which has recently prevented her from playing in her usual soccer tournaments on the weekends. Vitals are within normal limits. On physical examination, the skin over her hands, forearms and chest appears shiny and tight. Which of the following antibodies is most likely to be present on laboratory evaluation?
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