Thrombotic microangiopathy Quiz: Ace Your Exams

Get ready to dominate your medical and nursing exams by using our dynamic quizzes to elevate your knowledge and increase your confidence. Whether you're gearing up for the USMLE®, COMLEX®, or your next in-class assessment, Osmosis quizzes tackle key topics in pathology, diagnostics, and treatment approaches. By honing in on clinical readiness and decision-making, we make sure the knowledge you gain empowers you both in the classroom and in real-world practice. Jump in and supercharge your exam prep!

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A 41-year-old woman presents to the emergency department for evaluation of fatigue and generalized malaise for the past 2-3 days. She also reports non-specific abdominal cramping and nausea. Before this, the patient was in her usual health. She has no significant past medical history. Temperature is 38 (100.4) pulse is 104/min, respiratory rate is 18/min, and oxygen saturation is 99% on room air. The patient appears fatigued. Abdominal examination reveals mild generalized tenderness to palpation without rebound or guarding. Cardiac and pulmonary examinations are within normal limits. Blood work is obtained with results shown below. Peripheral blood smear shows schistocytes. ADAMTS13 activity level is significantly decreased, and an inhibitor is detected. Given the most likely diagnosis, which of the following additional features is most likely to be seen?

 CBC Result Reference Range
 Hemoglobin 7.9 g/dL 12-16 g/dL
 Mean corpuscular volume 80 fL 80-100 fL
 Leukocyte count 16,100 /mm3 4,500-11,000 /mm3
 Platelet count 20,000/mm3 150,000-400,000/mm3
 Creatinine 1.3 mg/dL 0.6-1.2 mg/dL
 INR 1.2 0.8-1.1

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