Vitamin K deficiency Quiz: Ace Your Exams

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A 31-year-old man comes to the office for the evaluation of bleeding from the gums and easy bruising. The patient reports that even minor trauma causes a bruise, and he sometimes bleeds spontaneously from his gums. He also complains of frequent fatigue, generalized weakness, and poor appetite. Past medical history is significant for Crohn disease that required a partial small bowel resection a year ago. The patient has also been receiving oral antibiotic treatment for a perianal fistula for the past 3 months. Family history is noncontributory. Vitals are within normal limits. Physical examination shows multiple large ecchymoses of the lower extremities and trace bleeding from the gums. Laboratory results are shown.

 
 Laboratory features 
 Laboratory value  Result 
 Platelet count    250,000/mm3 
 Bleeding time  5 minutes 
 Prothrombin time   29 seconds 
 Partial thromboplastin time  43 seconds 
 Bilirubin   
 Total   0.8 mg/dL 
 Direct  0.2 mg/dL 
 Alanine aminotransferase   15 U/L 
 Aspartate aminotransferase   17 U/L 


Which of the following is the most likely cause of this patient’s presentation?  

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