Skin cancer Quiz: Ace Your Exams

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A 55-year-old woman is brought to the emergency department by her partner following generalized tonic-clonic seizure activity. Her partner states that the patient has generally been in good health, but states that she has mentioned right-sided weakness over the past week. She has no significant past medical history. Temperature is 37.0°C (98.6°F), pulse is 96/min, respirations are 22/min, and blood pressure is 125/85 mmHg. Physical examination reveals a stuporous woman who is unable to speak coherently. Physical examination reveals mild right-sided weakness. A hyperpigmented lesion is noted on the dorsum of the right hand with irregular borders measuring 8-mm in diameter. Noncontrast CT of the brain is shown:

A head computed tomography scan shows multiple calcifications and ventricular dilation. This view is an axial slice, displaying brain structure.
Retrieved from: Radiopaedia.org
After confirming the diagnosis, a decision is made to start this patient on vemurafenib. Which of the following is the most likely mechanism of action of this drug?

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