Stevens-Johnson syndrome Quiz: Ace Your Exams

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A 38-year-old man is brought to the emergency department to evaluate diffuse skin blistering. Around four days ago, the patient developed fevers, muscle aches, and malaise. He attributed the symptoms to a viral infection. This morning, he noticed multiple bullae on his skin all over his body. He has also experienced ulceration and desquamation of the lips and oropharynx, which has made it difficult for him to eat or drink. The patient has recently been prescribed trimethoprim-sulfamethoxazole for cellulitis and acetaminophen to treat an ankle sprain. He has been taking lamotrigine for seizure prevention for the past ten years. He received a tetanus booster shot one week ago. Temperature is 39.2°C (103°F), blood pressure is 153/82 mmHg, and pulse is 93/min. Physical examination reveals the following:  


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Painful lesions are present over 5% of the patient’s skin. Which of the following factors most likely precipitated this patient’s current condition?  

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