Chediak-Higashi syndrome
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Chediak-Higashi syndrome
Immune system
Hypersensitivity reactions
Anaphylaxis
Asthma
Food allergy
Type I hypersensitivity
Autoimmune hemolytic anemia
Goodpasture syndrome
Graves disease
Hemolytic disease of the newborn
Myasthenia gravis
Pemphigus vulgaris
Rheumatic heart disease
Type II hypersensitivity
Poststreptococcal glomerulonephritis
Serum sickness
Systemic lupus erythematosus
Type III hypersensitivity
Contact dermatitis
Graft-versus-host disease
Type IV hypersensitivity
Immunodeficiences
Asplenia
Common variable immunodeficiency
Hyperimmunoglobulin E syndrome
IgG subclass deficiency
Isolated primary immunoglobulin M deficiency
Selective immunoglobulin A deficiency
X-linked agammaglobulinemia
Adenosine deaminase deficiency
Ataxia-telangiectasia
Hyper IgM syndrome
Severe combined immunodeficiency
Wiskott-Aldrich syndrome
Complement deficiency
Hereditary angioedema
Cytomegalovirus infection after transplant (NORD)
Post-transplant lymphoproliferative disorders (NORD)
Chediak-Higashi syndrome
Chronic granulomatous disease
Leukocyte adhesion deficiency
Immune system pathology review
Blood transfusion reactions and transplant rejection: Pathology review
Immunodeficiencies: Combined T-cell and B-cell disorders: Pathology review
Immunodeficiencies: Phagocyte and complement dysfunction: Pathology review
Immunodeficiencies: T-cell and B-cell disorders: Pathology review
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Chediak-Higashi syndrome
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Chediak-Higashi syndrome
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Summary
Chediak-Higashi syndrome is a rare, autosomal recessive genetic disorder in which a lysosomal trafficking regulator protein mutation leads to a decrease in phagocytosis. This predisposes individuals to recurrent pyogenic infections. People with Chediak-Higashi syndrome also have partial albinism and peripheral neuropathy. They can present with light skin color and hair that is blond, golden brown, or white. Other symptoms include poor vision and hearing, easy bruising and bleeding, and a heightened sensitivity to cold.
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