Transcript for Lupus
Systemic Lupus Erythematosus, or lupus, is an autoimmune disease, where essentially any tissue or organ can be the target of inflammation.
Often there are periods of illness, called flares, and periods of remission during which there are few symptoms.
The diagnosis of lupus is made when 4 or more out of 11 criteria are met.
The first three have to do with the skin.
The first is a malar rash, sometimes just called a “butterfly rash”, which is a rash over the cheeks that spares the nasolabial folds and appears after sun exposure.
Second is a discoid rash, which is chronic erythematous rash in sun-exposed areas like the arms and legs that are plaque-like or patchy redness and can scar.
Third, is a general photosensitivity of the skin — essentially a catch-all category for other rashes that happen to sun-exposed areas — typically only lasting a couple of days.
Lupus can also damage the inner membrane or mucosa of various tissues, so the fourth criteria is ulcers in the mouth or nose.
The fifth criteria is serositis which is inflammation of the serosa, which is like the outer membrane of an organ or tissue.
It can manifest as pleuritis, which is inflammation of the lining around the lungs and chest cavity; as pericarditis, which is inflammation of the lining of the heart; or as peritonitis, which is inflammation of the lining of the abdomen.
Now, in addition to pericarditis, it’s worth noting that lupus can also cause inflammation of the myocardium, leading to myocarditis, or the endocardium, leading to Libman-Sacks endocarditis, where clumps of fibrin and immune cells form vegetations on the mitral valve.
The sixth criteria is arthritis, and two or more joints have to get inflammed to meet the criteria.
The seventh criteria is evidence of kidney damage based on protein or cells in the urine.
It’s generally caused by lupus nephritis, which is a type of glomerulonephritis due to immune complex deposition along the glomerular basement membrane.
Lupus nephritis can ultimately lead to end-stage kidney failure, which is the leading cause of morbidity and mortality among individuals with lupus.
The ninth criteria is having autoantibodies against blood components causing cell destruction, and leading to conditions like anemia, thrombocytopenia, or leukopenia.
The final two criteria have to do with having specific antibodies in the blood.
The tenth criteria is having antinuclear antibody or ANA, which targets nuclear antigens.
Now a large proportion of patients with lupus have these, meaning this test is very sensitive, but it isn’t very specific, because it can be found in other autoimmune diseases.
The eleventh criteria is having one of three other autoantibodies.
The first is anti-Smith, which is an antibody against small ribonucleoproteins.
The second is anti-dsDNA, which is against double stranded DNA and is often seen more during flares, especially in individuals with kidney involvement.
These two are relatively specific for lupus.
The third type of antibody is antiphospholipid, which is actually an antibody that’s made against proteins that are bound to phospholipids, and is less specific for lupus, meaning that it can pop up in other situations.
There are three types of antiphospholipid antibodies.
The other two antiphospholipid antibodies are lupus anticoagulant also called lupus antibody, and anti-beta2 glycoprotein I.
Sometimes, because of these, patients with lupus develop an antiphospholipid syndrome, where the antiphospholipid antibodies cause a hypercoagulable state, meaning they’re more prone to developing clots and having complications like deep vein thrombosis, hepatic vein thrombosis, and stroke.
Now, lupus can also cause additional symptoms that aren’t part of the diagnostic criteria.
Systemic symptoms include fever, fatigue, myalgia, unintentional weight loss, and lymphadenopathy.
There can also be vasculitis, which can manifest as palpable purpura, petechiae, panniculitis, skin ulcers, splinter hemorrhages, and livedo reticularis - which is where there’s a lace-like purplish discoloration of the skin.
Another vascular condition that can occur in lupus is Raynaud’s phenomenon, which is where arterial spasm causes reduced blood flow to the fingers.
It typically lasts for minutes, and the fingers turn white and then blue, often with numbness or pain, and then as blood flow returns, the fingers turn red and burn.
Finally, lupus increases the likelihood of thromboembolic disease, specifically a blood clot can form in a blood vessel and then breakaway to plug up a smaller vessel in another organ like the lungs, brain, or kidneys.