Conn syndrome

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Conn syndrome

Pathology

Adrenal disorders

Adrenal cortical carcinoma
Conn syndrome
Cushing syndrome
Hyperaldosteronism
Primary adrenal insufficiency
Waterhouse-Friderichsen syndrome
Neuroblastoma
Opsoclonus myoclonus syndrome (NORD)
Pheochromocytoma

Congenital disorders

5-alpha-reductase deficiency
Androgen insensitivity syndrome
Congenital adrenal hyperplasia
Kallmann syndrome
Thyroglossal duct cyst

Diabetes mellitus and other disorders of the endocrine pancreas

Diabetes mellitus
Diabetic nephropathy
Diabetic retinopathy
Pancreatic neuroendocrine neoplasms
Zollinger-Ellison syndrome

Multiple endocrine neoplasia (MEN1, MEN2)

Multiple endocrine neoplasia

Neuroendocrine tumors

Carcinoid syndrome
Pancreatic neuroendocrine neoplasms
Zollinger-Ellison syndrome

Parathyroid disorders

Hyperparathyroidism
Hypoparathyroidism

Pituitary disorders

Hyperprolactinemia
Pituitary adenoma
Prolactinoma
Delayed puberty
Premature ovarian failure
Constitutional growth delay
Growth hormone deficiency
Hypopituitarism
Hypoprolactinemia
Pituitary apoplexy
Sheehan syndrome
Diabetes insipidus
Syndrome of inappropriate antidiuretic hormone secretion (SIADH)

Thyroid gland disorders

Graves disease
Hyperthyroidism
Thyroid eye disease (NORD)
Thyroid storm
Toxic multinodular goiter
Euthyroid sick syndrome
Hashimoto thyroiditis
Hypothyroidism
Postpartum thyroiditis
Riedel thyroiditis
Subacute granulomatous thyroiditis
Thyroid cancer

Other disorders

Autoimmune polyglandular syndrome type 1 (NORD)

Endocrine system pathology review

Adrenal masses: Pathology review
Cushing syndrome and Cushing disease: Pathology review
Disorders of sex chromosomes: Pathology review
Disorders of sexual development and sex hormones: Pathology review
Diabetes mellitus: Pathology review
Neuroendocrine tumors of the gastrointestinal system: Pathology review
Multiple endocrine neoplasia: Pathology review
Parathyroid disorders and calcium imbalance: Pathology review
Diabetes insipidus and SIADH: Pathology review
Hypopituitarism: Pathology review
Pituitary tumors: Pathology review
Hyperthyroidism: Pathology review
Hypothyroidism: Pathology review
Thyroid nodules and thyroid cancer: Pathology review

Flashcards

Conn syndrome

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Questions

USMLE® Step 1 style questions USMLE

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A 41-year-old woman returns to the clinic after a high blood pressure reading 1 week ago. She has also been experiencing fatigue and muscle weakness over the past month. Past medical history is noncontributory. Her blood pressure is 159/94 mmHg at today’s visit. Physical examination shows no abnormalities. Serum studies reveal a potassium concentration of 3.2 mEq/L. The plasma aldosterone concentration to plasma renin activity ratio is significantly elevated. Abdominal CT reveals bilateral adrenal gland masses. The patient is prescribed an aldosterone receptor antagonist. Which of the following medications was most likely provided?  

Key Takeaways

Conn syndrome, also known as primary hyperaldosteronism, is a rare disorder caused by high levels of aldosterone hormone. Aldosterone is produced by the adrenal gland, promotes Sodium conservation in the kidney, and helps the body keep Sodium and water balance.

In Conn syndrome, the adrenal gland produces too much aldosterone, and this causes the body to retain too much salt and water. This can lead to high blood pressure, edema, and hypokalemia (low potassium levels in the blood). Conn syndrome can be caused by adrenal hyperplasia or adrenal adenoma.