Crigler-Najjar syndrome
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Crigler-Najjar syndrome
Gastrointestinal system
Liver, gallbladder and pancreas disorders
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Crigler-Najjar syndrome
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Gastrointestinal system pathology review
Appendicitis: Pathology review
Cirrhosis: Pathology review
Colorectal polyps and cancer: Pathology review
Congenital gastrointestinal disorders: Pathology review
Diverticular disease: Pathology review
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Malabsorption syndromes: Pathology review
Neuroendocrine tumors of the gastrointestinal system: Pathology review
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Crigler-Najjar syndrome
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0 / 5 complete
USMLE® Step 1 questions
0 / 3 complete
High Yield Notes
6 pages
Flashcards
Crigler-Najjar syndrome
of complete
Questions
USMLE® Step 1 style questions USMLE
of complete
| Laboratory value | Result |
| Hemoglobin | 13.9 mg.dL |
| Leukocyte count | 6,800/mm3 |
| Total bilirubin | 12.7 mg/dL |
| Conjugated bilirubin | 0.3 mg/dL |
| Alanine aminotransferase | 15 U/L |
| Aspartate aminotransferase | 16 U/L |
External References
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Crigler-Najjar syndrome p. 402, 403
presentation p. 718
Jaundice p. 402
Crigler-Najjar syndrome p. 718
Summary
Crigler-Najjar syndrome is an inherited disorder that affects the ability to break down bilirubin, a pigment produced when red blood cells are broken down. Crigler-Najjar syndrome is caused by the absence (type I) or reduced activity (type II) of the enzyme UDP-glucuronosyltransferase, and people having this disease present with high levels of bilirubin in their blood, which can cause yellowing of the skin and eyes (jaundice), dark urine, lightheadedness, confusion, and coma. The severity of symptoms varies among people with this condition.
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