AssessmentsDisorders of consciousness: Clinical practice
USMLE® Step 1 style questions USMLE
USMLE® Step 2 style questions USMLE
A 53-year-old male comes to the emergency department because of extremely high fever. He is diagnosed with severe sepsis and his state continues to depreciate. After 6 days, he becomes unresponsive to painful stimulus and brain death is suspected. Which of the following is not associated with the evaluation of brain-stem reflexes?
One of the many higher-order functions of our brains is maintaining consciousness.
Consciousness includes both arousal or wakefulness, as well as awareness.
The ARAS sends out neuronal connections to both cerebral cortices, which are responsible for producing awareness.
Now, the differential diagnosis for coma is large, but they fall into 4 broad categories: toxic, such as opioid toxicity, infectious, such as sepsis or meningitis and encephalitis, metabolic, which includes electrolyte imbalances or organ dysfunction, and structural, such as a stroke or subdural hemorrhage.
When a person is found to already be in a comatose state, it’s helpful to get information from witnesses, family members, friends, and paramedics, as well as from medical alert bracelets.
If the comatose state had an abrupt onset it may be due to stroke, seizure, subarachnoid hemorrhage, or cardiac arrest. Whereas a gradual onset may be due to a brain tumor, subdural hematoma, infection, or metabolic disorder.
A history of a fall may suggest traumatic brain injury, while a recent fever may suggest infection.
Additionally, empty pill bottles, a suicide note, or a history of psychiatric disease like depression or schizophrenia are clues to a suicidal overdose. Young children can also accidentally overdose on medications in the household.
The past medical history is extremely helpful. For example, in an individual with diabetes, hypoglycemia and hyperglycemic states like diabetic ketoacidosis or hyperglycemic hyperosmolar state should be considered.
Another cause are electrolyte imbalances which can cause coma, as well as rapid correction of electrolyte imbalances. For example, rapid correction of hyponatremia can cause central osmotic demyelination syndrome, whereas rapid correction of hypernatremia may cause cerebral edema, both of which can cause coma.
Finally, it’s important to review all the individual’s medications that may potentially alter the individual’s level of consciousness.
A common breathing pattern in comatose individuals is Cheyne-Stokes respirations, which are waxing and waning periods of gradually increasing, heavy and fast breathing called hyperpnea, followed by gradually decreasing, slow breathing called hypopnea, which is followed by total cessation of breathing, or apnea. This occurs anytime the brainstem doesn’t receive enough oxygen, such in a stroke or heart failure.
Kussmaul’s respirations are characterized by deep, laboured breathing, and suggest an acidotic state, like diabetic ketoacidosis.
On fundoscopic examination of the eyes, subhyaloid hemorrhages may indicate a subarachnoid hemorrhage, exudates may clue towards hypertensive encephalopathy, and papilledema indicates an increased intracranial pressure.
For example, a GCS score less than 8 may be an indication for intubation.
However, the GCS was not developed to diagnose a coma.
The GCS score has 3 parts: eye movement, verbal response, and motor response.
For eye movement, if the individual spontaneously opens their eyes, that’s 4 points. If they open their eyes only when asked, that’s 3 points. If they open their eyes only with a mild amount of pain like rubbing the orbit of the eye, that’s 2 points. If they don’t open their eyes, that’s 1 point.
For verbal response, if the individual can say what year it is, that’s 5 points. If they get the year wrong, that’s 4 points. If they respond with inappropriate words, like “yesterday or dog”, that’s 3 points. If they respond with a sound like a moan, that’s 2 points. If they don’t respond, that’s 1 point.
For motor response, if the individual can obey a motor command, like: “show me three fingers”, that’s 6 points. If not, you can rub the orbit of the eye, and if they smack your hand out of the way, then they’re localizing well, and that’s 5 points. If not, you can prick the tip of their finger, and if they withdraw, that’s 4 points. If not, if the upper limbs are flexed and lower limbs are extended, then that’s 3 points. If the upper and lower limbs are extended, that’s 2 points. Finally, if there is absolutely no tone, that’s 1 point.
To remember the point system, think “4 eyes” for eye movement, the “Jackson 5” for verbal response, and a “6 cylinder motor” for the motor response.
When shining a light on the pupils - pinpoint, unreactive pupils may indicate structural damage to the pons, or an opioid overdose. A unilateral, dilated, unreactive pupil suggests an expanding intracranial mass causing cerebral herniation and compression of the 3rd cranial nerve. Bilateral, dilated, unreactive pupils may indicate an overdose of amphetamines, cocaine, or tricyclic antidepressants. Fixed, mid-sized pupils are classic for a midbrain injury. Interestingly, the pupils are usually spared in metabolic disorders causing coma.
Finally, the vestibulo-ocular reflex is assessed in two ways: the oculocephalic, or “doll’s eye” maneuver, or the more sensitive caloric test. In the doll’s eye maneuver, the head is abruptly turned from one side to the other. In a normally functioning brainstem, the eyes move in the opposite direction. For example, turning the head to the left should cause the eyes to move to the right. Brainstem dysfunction should be suspected if the eyes move in the same direction as the head.
As for caloric testing, the external auditory canal is irrigated with cold ice water. Normally, the eyes deviate towards the ear canal being irrigated. Absence of an eye response raises suspicion for brainstem dysfunction.
Alright, next comes the motor exam. Since the individual is comatose, you cannot assess muscle power, however, you can assess posture, and muscle tone.
Posture is like a cheap GPS device, it’ll tell you where the lesion is roughly, but not exactly.