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Dubin-Johnson syndrome

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Dubin-Johnson syndrome

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Breast cancer: Clinical
Benign breast conditions: Pathology review
Postoperative evaluation: Clinical
General anesthetics
Local anesthetics
Neuromuscular blockers
Whipple's disease
Protein losing enteropathy
Gallstone ileus
Intestinal adhesions
Small bowel ischemia and infarction
Ischemic colitis
Familial adenomatous polyposis
Colorectal polyps
Carcinoid syndrome
Diverticulosis and diverticulitis
Rectal prolapse
Anal fistula
Gilbert's syndrome
Biliary atresia
Crigler-Najjar syndrome
Dubin-Johnson syndrome
Cirrhosis
Portal hypertension
Hemochromatosis
Budd-Chiari syndrome
Jaundice
Hepatic encephalopathy
Wilson disease
Non-alcoholic fatty liver disease
Alcohol-associated liver disease
Primary sclerosing cholangitis
Reye syndrome
Viral hepatitis
Hepatocellular carcinoma
Laxatives and cathartics
Antidiarrheals
Diabetes mellitus: Clinical
Hypothyroidism and thyroiditis: Clinical
Neck trauma: Clinical
Insulins
Mineralocorticoids and mineralocorticoid antagonists
Glucocorticoids

Key Takeaways

Dubin-Johnson syndrome is a rare autosomal genetic disorder characterized by some elevation of conjugated bilirubin but no other signs of injury to the hepatocytes. It's also associated with a black liver due to the deposition of a pigment similar to melanin. Dubin-Johnson syndrome is generally asymptomatic, and no treatment is usually needed.

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Dubin-Johnson syndrome

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A 51-year-old man comes to the internal medicine PA for evaluation of epigastric abdominal pain and unintentional weight loss. The symptoms began 6 months ago and the patient has lost 4 kg (8.8 lb) during this time period. Review of systems is notable for fatigue and pruritus over this same time period. Past medical history is notable for alcohol use disorder. The patient has a 35-pack-year smoking history. In the office, his temperature is 37.6°C (99.7°F), blood pressure is 125/77 mmHg, and pulse is 72/min. Physical examination shows an enlarged, palpable, but non-tender, gallbladder. Examination of the patient’s eyes reveals the following finding:  



Cardiac and pulmonary exams are noncontributory. Serum carbohydrate antigen 19-9 levels are elevated. Which of the following laboratory findings would most likely be present in this patient?