Video - Miscellaneous protein synthesis inhibitors

00:00 / 00:00
More Videos

04:07
Mechanisms of antibiotic resistance

10:46
Antimetabolites: Sulfonamides and trimethoprim

15:13
Antituberculosis medications

15:07
Cell wall synthesis inhibitors: Cephalosporins

13:49
Cell wall synthesis inhibitors: Penicillins

07:11
DNA synthesis inhibitors: Fluoroquinolones

05:24
DNA synthesis inhibitors: Metronidazole

15:09
Miscellaneous cell wall synthesis inhibitors

16:32
Miscellaneous protein synthesis inhibitors

11:25
Protein synthesis inhibitors: Aminoglycosides

10:45
Protein synthesis inhibitors: Tetracyclines
Video Summary
Protein synthesis inhibitors are a class of antibiotics which prevent bacterial ribosomes from synthesizing proteins. They include drugs like chloramphenicol, macrolides, lincosamides, and oxazolidinones.
Most of these drugs act on the 50S subunit of the ribosome, but their mechanisms can be very different. For example, oxazolidinones like linezolid stop the initiation complex from forming. Both the macrolides and lincosamides prevent translocation. Chloramphenicol inhibits peptidyl transferase which is the enzyme that creates the peptide bonds.