Osmosis video - Primary adrenal insufficiency

Primary adrenal insufficiency, also known as Addison's disease, is a chronic condition in which the adrenal glands fail to produce enough cortisol and mineralocorticoid hormones. This can be caused by an autoimmune disorder, infection, or causes of damage to the adrenal glands. Symptoms may include fatigue, weight loss, muscle weakness, low blood pressure, and darkening of the skin. Treatment involves replacement of cortisol and mineralocorticoid hormones, as well as treating any underlying cause.