Osmosis video - Waldenstrom macroglobulinemia (NORD)

Waldenstrom Macroglobulinemia, or Waldenstrom syndrome, is a rare type of malignant lymphoma that's characterized by the overproduction of an antibody called immunoglobulin M (IgM) in the blood, which can lead to hyperviscosity syndrome (thickening of the blood) and interferes with normal blood circulation.

Symptoms can include fatigue, weakness, an enlarged spleen or lymph nodes, and bleeding or clotting problems. Diagnosis is through blood tests, bone marrow biopsy, and other imaging studies. Treatment options depend on the severity of the disease, as well as the patient's overall health and other individual factors. Options may include chemotherapy, targeted therapy, immunomodulatory drugs, stem cell transplantation, and supportive care.