Osmosis video - Stevens-Johnson syndrome

Stevens �Johnson syndrome is a life-threatening skin condition, in which cell death causes the epidermis to separate from the dermis. It is a type of IV hypersensitivity reaction where cytotoxic T-cells inappropriately attack and kill epithelial cells in the mucosa and skin epidermis. The most well-known causes are medications, such as lamotrigine and other seizure drugs. Treatment includes immediately removing the trigger, followed by pain medication, hydration, and sterile wound care.