Costochondritis can be diagnosed clinically based on the findings from the medical history and physical exam. The most characteristic sign of costochondritis is pain and tenderness upon palpation of the affected area. Oftentimes, costochondritis is confused with Tietze syndrome, a similar but less common disorder that causes swelling of a single costal cartilage, usually of the second or third rib. Unlike Tietze syndrome, costochondritis causes diffuse pain and is generally not associated with any swelling or induration of the costochondral joints.
In individuals with suspected
costochondritis, additional tests are not necessary for the diagnosis unless diagnosis is uncertain or if fever or signs of inflammation are present. In individuals with a history or risk of
heart disease, additional tests may be conducted to rule out other causes of chest pain, such as a
heart attack. Other medical conditions that may need to be ruled out include
pneumonia,
pneumothorax,
pulmonary embolism, or
rib fractures among others. Depending on the clinical suspicion, additional testing may involve an
electrocardiogram (ECG),
chest X-ray, or laboratory investigations.