Developmental milestones (newborn and infant): Clinical sciences

Last updated: June 20, 2025

Developmental milestones (newborn and infant): Clinical sciences

Prometric syllabus

Prometric syllabus

Essential hypertension: Clinical sciences
Congestive heart failure: Clinical sciences
Aortic stenosis: Clinical sciences
Aortic dissection: Clinical sciences
Abdominal aortic aneurysm: Clinical sciences
Valvular insufficiency (regurgitation): Clinical sciences
Mitral stenosis: Clinical sciences
Pericarditis: Clinical sciences
Infectious endocarditis: Clinical sciences
Asthma: Clinical sciences
Asthma in pregnancy: Clinical sciences
Chronic obstructive pulmonary disease: Clinical sciences
Pulmonary hypertension: Clinical sciences
Community-acquired pneumonia: Clinical sciences
Hospital-acquired and ventilator-associated pneumonia: Clinical sciences
Tuberculosis (pulmonary): Clinical sciences
Tuberculosis (extrapulmonary and latent): Clinical sciences
Pulmonary embolism: Clinical sciences
Deep vein thrombosis: Clinical sciences
Pleural effusion: Clinical sciences
Pneumothorax: Clinical sciences
Peptic ulcer disease: Clinical sciences
Gastroesophageal reflux disease: Clinical sciences
Acute pancreatitis: Clinical sciences
Chronic pancreatitis: Clinical sciences
Inflammatory bowel disease (Crohn disease): Clinical sciences
Inflammatory bowel disease (ulcerative colitis): Clinical sciences
Cirrhosis: Clinical sciences
Hepatitis B: Clinical sciences
Hepatitis C: Clinical sciences
Alcohol-induced hepatitis: Clinical sciences
Approach to ascites: Clinical sciences
Approach to hepatic masses: Clinical sciences
Gastroesophageal varices: Clinical sciences
Approach to upper abdominal pain: Clinical sciences
Hepatitis A and E: Clinical sciences
Approach to jaundice (conjugated hyperbilirubinemia): Clinical sciences
Approach to jaundice (unconjugated hyperbilirubinemia): Clinical sciences
Approach to jaundice (newborn and infant): Clinical sciences
Pancreatic cancer: Clinical sciences
Approach to pancreatic masses: Clinical sciences
Choledocholithiasis and cholangitis: Clinical sciences
Portal vein thrombosis: Clinical sciences
Primary biliary cholangitis and primary sclerosing cholangitis: Clinical sciences
Cholestatic liver disease
Infectious gastroenteritis: Clinical sciences
Approach to diarrhea (pediatrics): Clinical sciences
Infectious gastroenteritis (acute) (pediatrics): Clinical sciences
Infectious gastroenteritis (subacute) (pediatrics): Clinical sciences
Approach to vomiting (newborn and infant): Clinical sciences
Diabetes mellitus (Type 2): Clinical sciences
Diabetes mellitus (Type 1): Clinical sciences
Diabetes mellitus (pediatrics): Clinical sciences
Diabetes in pregnancy (GDM, T1DM, and T2DM): Clinical sciences
Diabetes insipidus: Clinical sciences
Approach to diabetes in pregnancy: Clinical sciences
Diabetic ketoacidosis: Clinical sciences
Thyroid nodules: Clinical sciences
Approach to hypothyroidism: Clinical sciences
Approach to hyperthyroidism and thyrotoxicosis: Clinical sciences
Thyroid carcinoma: Clinical sciences
Hashimoto thyroiditis: Clinical sciences
Adrenal insufficiency: Clinical sciences
Approach to adrenal masses: Clinical sciences
Pheochromocytoma: Clinical sciences
Approach to postoperative hypotension: Clinical sciences
Cushing syndrome and Cushing disease: Clinical sciences
Gastritis: Clinical sciences
Multiple endocrine neoplasia: Clinical sciences
Approach to precocious puberty: Clinical sciences
Prerenal acute kidney injury: Clinical sciences
Intrinsic acute kidney injury (non-glomerular causes): Clinical sciences
Postrenal acute kidney injury: Clinical sciences
Approach to acute kidney injury: Clinical sciences
Intrinsic acute kidney injury (glomerular causes): Clinical sciences
Approach to postoperative acute kidney injury: Clinical sciences
Chronic kidney disease: Clinical sciences
Nephrotic syndromes (pediatrics): Clinical sciences
Nephritic syndromes (pediatrics): Clinical sciences
Uremic encephalopathy: Clinical sciences
Approach to hyperkalemia: Clinical sciences
Approach to hypokalemia: Clinical sciences
Approach to hyponatremia: Clinical sciences
Approach to hyponatremia (pediatrics): Clinical sciences
Syndrome of inappropriate antidiuretic hormone secretion: Clinical sciences
Urinary tract infection (pediatrics): Clinical sciences
Catheter-associated urinary tract infection: Clinical sciences
Urinary retention: Clinical sciences
Urinary tract infections and kidney stones in pregnancy: Clinical sciences
Nephrolithiasis: Clinical sciences
Stress, urge, overflow, and mixed urinary incontinence (GYN): Clinical sciences
Lower urinary tract infection: Clinical sciences
Pyelonephritis: Clinical sciences
Approach to dysuria: Clinical sciences
Iron deficiency anemia: Clinical sciences
Iron deficiency and iron deficiency anemia (pediatrics): Clinical sciences
Hemochromatosis: Clinical sciences
Anemia in pregnancy: Clinical sciences
Approach to anemia in the newborn and infant (underproduction): Clinical sciences
Hemoglobinopathies in pregnancy: Clinical sciences
Approach to anemia (underproduction): Clinical sciences
Vitamin B12 deficiency: Clinical sciences
Thrombotic microangiopathy: Clinical sciences
Approach to anemia (destruction and sequestration): Clinical sciences
Approach to bleeding disorders (thrombocytopenia): Clinical sciences
Approach to leukemia: Clinical sciences
Approach to lymphoma: Clinical sciences
Disseminated intravascular coagulation: Clinical sciences
Immune thrombocytopenia: Clinical sciences
Sepsis (pediatrics): Clinical sciences
Sepsis: Clinical sciences
Neonatal respiratory distress syndrome: Clinical sciences
Approach to cyanosis (newborn): Clinical sciences
Immunizations (pediatrics): Clinical sciences
Approach to viral exanthems (pediatrics): Clinical sciences
Meningitis (pediatrics): Clinical sciences
Pneumonia (pediatrics): Clinical sciences
Croup and epiglottitis: Clinical sciences
Celiac disease: Clinical sciences
Intussusception: Clinical sciences
Pharyngitis, peritonsillar abscess, and retropharyngeal abscess (pediatrics): Clinical sciences
Approach to poor feeding (newborn and infant): Clinical sciences
Approach to trauma (pediatrics): Clinical sciences
Approach to congenital heart diseases (acyanotic): Clinical sciences
Protein-calorie malnutrition: Clinical sciences
Well-patient care (GYN): Clinical sciences
Sexually transmitted infection screening (GYN): Clinical sciences
Antepartum care (first trimester): Clinical sciences
Antepartum care (second trimester): Clinical sciences
Antepartum care (third trimester): Clinical sciences
Approach to postpartum hemorrhage: Clinical sciences
Vaginal birth after cesarean (VBAC): Clinical sciences
Approach to third trimester bleeding: Clinical sciences
Approach to first trimester bleeding: Clinical sciences
Gestational hypertension, preeclampsia, eclampsia, and HELLP: Clinical sciences
Approach to hypertensive disorders in pregnancy: Clinical sciences
Chronic hypertension in pregnancy: Clinical sciences
Preconception care: Clinical sciences
Gestational trophoblastic disease (GTD) and neoplasia (GTN): Clinical sciences
Maternal D alloimmunization (management): Clinical sciences
Maternal D alloimmunization (prevention): Clinical sciences
Fetal growth restriction: Clinical sciences
Prelabor rupture of membranes: Clinical sciences
Preterm labor: Clinical sciences
Induction of labor: Clinical sciences
Cytomegalovirus (CMV), parvovirus B19, varicella zoster, and toxoplasmosis infection in pregnancy: Clinical sciences
Intrapartum fetal heart rate monitoring: Clinical sciences
Intrapartum care (1st, 2nd, 3rd, and 4th stages): Clinical sciences
Ectopic pregnancy: Clinical sciences
Approach to respiratory distress (newborn): Clinical sciences
Shoulder dystocia: Clinical sciences
Late-term and postterm pregnancy: Clinical sciences
Group B streptococcus (GBS) colonization in pregnancy: Clinical sciences
Approach to abnormal uterine bleeding in reproductive-aged patients: Clinical sciences
Approach to dysmenorrhea: Clinical sciences
Primary dysmenorrhea: Clinical sciences
Approach to chronic pelvic pain (GYN): Clinical sciences
Endometriosis: Clinical sciences
Adenomyosis: Clinical sciences
Approach to adnexal masses: Clinical sciences
Intimate partner violence and sexual assault: Clinical sciences
Pelvic inflammatory disease: Clinical sciences
Uterine leiomyoma: Clinical sciences
Infertility: Clinical sciences
Approach to postmenopausal bleeding: Clinical sciences
Placenta previa
Early pregnancy loss: Clinical sciences
Ovarian cancer: Clinical sciences
Perimenopause, menopause, and primary ovarian insufficiency: Clinical sciences
Polycystic ovary syndrome (PCOS): Clinical sciences
Neisseria gonorrhoeae infection: Clinical sciences
Sexually transmitted infection screening (Family medicine): Clinical sciences
Approach to vaginal discharge: Clinical sciences
Reactive arthritis: Clinical sciences
Approach to joint pain and swelling: Clinical sciences
Chlamydia trachomatis infection: Clinical sciences
Non-accidental trauma and neglect (pediatrics): Clinical sciences
Pain management during labor: Clinical sciences
Approach to postpartum fever: Clinical sciences
Aspiration pneumonia and pneumonitis: Clinical sciences
Herpes simplex virus infection in pregnancy: Clinical sciences
Protraction and arrest disorders: Clinical sciences
Placenta accreta spectrum: Clinical sciences
Placental abruption: Clinical sciences
Cholestasis of pregnancy: Clinical sciences
Venous thromboembolism in pregnancy: Clinical sciences
Approach to congenital infections: Clinical sciences
Perinatal depression and anxiety: Clinical sciences
Intraamniotic infection: Clinical sciences
Antepartum fetal surveillance: Clinical sciences
Permanent contraception (sterilization): Clinical sciences
Abdominal trauma in pregnancy: Clinical sciences
Placenta previa and vasa previa: Clinical sciences
Approach to the acute abdomen (pediatrics): Clinical sciences
Approach to abdominal wall and groin masses: Clinical sciences
Appendicitis: Clinical sciences
Small bowel obstruction: Clinical sciences
Inguinal hernias: Clinical sciences
Large bowel obstruction: Clinical sciences
Short bowel syndrome: Clinical sciences
Irritable bowel syndrome: Clinical sciences
Esophageal perforation: Clinical sciences
Approach to pneumoperitoneum and peritonitis (perforated viscus): Clinical sciences
Intra-abdominal abscess: Clinical sciences
Approach to a postoperative fever: Clinical sciences
Stress ulcers: Clinical sciences
Approach to traumatic brain injury (pediatrics): Clinical sciences
Bladder injury: Clinical sciences
Pressure-induced skin and soft tissue injury: Clinical sciences
Approach to blunt chest injury: Clinical sciences
Approach to blunt and penetrating abdominal injury: Clinical sciences
Approach to blunt cerebrovascular injury: Clinical sciences
Approach to traumatic brain injury: Clinical sciences
Approach to penetrating chest injury: Clinical sciences
Approach to postoperative wound complications: Clinical sciences
Approach to non-healing wounds: Clinical sciences
Burns: Clinical sciences
Major depressive disorder and persistent depressive disorder (dysthymia): Clinical sciences
Approach to mood disorders: Clinical sciences
Approach to fatigue: Clinical sciences
Approach to unintentional weight loss: Clinical sciences
Bipolar I, bipolar II, and cyclothymic disorder: Clinical sciences
Approach to gradual cognitive decline: Clinical sciences
Parkinson disease and dementia with Lewy bodies: Clinical sciences
Approach to trauma and stressor-related disorders: Clinical sciences
Alzheimer disease: Clinical sciences
Approach to hallucinogen, inhalant, and cannabis use, intoxication, and overdose: Clinical sciences
Myocarditis: Clinical sciences
Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD): Clinical sciences
Approach to anxiety disorders: Clinical sciences
Specific phobia and social anxiety disorder (social phobia): Clinical sciences
Generalized anxiety disorder, agoraphobia, and panic disorder: Clinical sciences
Approach to somatic symptom and related disorders: Clinical sciences
Approach to avoidant, dependent, and obsessive-compulsive (cluster C) personality disorders: Clinical sciences
Obsessive compulsive disorder (OCD): Clinical sciences
Tobacco use: Clinical sciences
Approach to benzodiazepine and barbiturate use, intoxication, and overdose: Clinical sciences
Alcohol withdrawal: Clinical sciences
Approach to paranoid, schizoid, and schizotypal (cluster A) personality disorders: Clinical sciences
Substance use disorder: Clinical sciences
Opioid use disorder: Clinical sciences
Approach to recreational substance exposure (pediatrics): Clinical sciences
Approach to stimulant use, intoxication, and overdose: Clinical sciences
Alcohol, tobacco, cannabinoid, and substance use in pregnancy: Clinical sciences
Approach to antisocial, borderline, histrionic, and narcissistic (cluster B) personality disorders: Clinical sciences
Alcohol use disorder: Clinical sciences
Approach to delay or regression in developmental milestones: Clinical sciences
Developmental milestones (newborn and infant): Clinical sciences
Delirium: Clinical sciences
Graves disease: Clinical Sciences
Approach to altered mental status (pediatrics): Clinical sciences
Approach to altered mental status: Clinical sciences
Approach to metabolic alkalosis: Clinical sciences
Approach to schizophrenia spectrum and other psychotic disorders: Clinical sciences
Systemic lupus erythematosus: Clinical sciences
Approach to nosocomial infections: Clinical sciences
Necrotizing soft tissue infections: Clinical sciences
Clostridioides difficile infection: Clinical sciences
Surgical site infection: Clinical sciences
Staphylococcal scalded skin syndrome and impetigo: Clinical sciences
Acute group A streptococcal infections and sequelae (pediatrics): Clinical sciences
Approach to bacterial causes of fever and rash (pediatrics): Clinical sciences
Approach to skin and soft tissue infections: Clinical sciences
Periorbital and orbital cellulitis (pediatrics): Clinical sciences
Acute rheumatic fever and rheumatic heart disease: Clinical sciences
Cellulitis and erysipelas: Clinical sciences
Approach to common skin rashes: Clinical sciences
Skin cancer screening: Clinical sciences
Melanoma: Clinical sciences
Basal cell carcinoma: Clinical sciences
Otitis media and externa (pediatrics): Clinical sciences
Upper respiratory tract infections: Clinical sciences
Approach to dizziness and vertigo: Clinical sciences
Approach to syncope: Clinical sciences
Approach to acute vision loss: Clinical sciences
Approach to a red eye: Clinical sciences
Conjunctival disorders: Clinical sciences
Glaucoma: Clinical sciences
Inflammatory breast cancer: Clinical sciences
Approach to diplopia: Clinical sciences
Hypovolemic shock: Clinical sciences
Neurogenic shock: Clinical sciences
Toxic shock syndrome: Clinical sciences
Approach to shock: Clinical sciences
Approach to shock (pediatrics): Clinical sciences
Multiple organ dysfunction syndrome (MODS): Clinical sciences
Spinal fractures: Clinical sciences
Approach to household substance exposure (pediatrics): Clinical sciences
Opioid intoxication and overdose: Clinical sciences
Anaphylaxis: Clinical sciences
Hypothermia: Clinical sciences
Malignant hyperthermia: Clinical sciences
Incidence and prevalence
Study designs
Cohort study
Cross sectional study
Case-control study
Approach to pneumoconiosis: Clinical sciences
Colorectal cancer screening: Clinical sciences
Cervical cancer screening: Clinical sciences
Breast cancer screening: Clinical sciences
Cardiovascular disease screening: Clinical sciences
Carotid artery stenosis screening: Clinical sciences
Temporal arteritis: Clinical sciences
Psoriatic arthritis: Clinical sciences
Rheumatoid arthritis: Clinical sciences
Septic arthritis: Clinical sciences
Septic arthritis and transient synovitis (pediatrics): Clinical sciences
Juvenile idiopathic arthritis: Clinical sciences
Systemic sclerosis (scleroderma): Clinical sciences
Osteoporosis: Clinical sciences
Osteoarthritis: Clinical sciences
Approach to foot pain: Clinical sciences
Approach to ankle pain: Clinical sciences
Systemic lupus erythematosus (SLE): Pathology review
Calcium pyrophosphate deposition disease (pseudogout): Clinical sciences
Gout: Clinical sciences
Approach to cystic kidney disease: Clinical sciences
Approach to a fever (over 2 months): Clinical sciences
Acute stroke (ischemic or hemorrhagic) or TIA: Clinical sciences
Subarachnoid hemorrhage: Clinical sciences
Approach to epilepsy: Clinical sciences
Approach to convulsive status epilepticus: Clinical sciences
Approach to a first unprovoked seizure (pediatrics): Clinical sciences
Febrile seizure (pediatrics): Clinical sciences
Approach to involuntary movements: Clinical sciences
Approach to unsteadiness, gait disturbance, or falls: Clinical sciences
Approach to headache or facial pain: Clinical sciences
Primary headaches (tension, migraine, and cluster): Clinical sciences
Approach to a fever in the returned traveler: Clinical sciences
Idiopathic intracranial hypertension: Clinical sciences
Benign prostatic hypertrophy and prostate cancer: Clinical sciences
Erectile dysfunction
Well-patient care (geriatrics): Clinical sciences
Approach to chest pain: Clinical sciences
Chronic mesenteric ischemia: Clinical sciences
Acute coronary syndrome: Clinical sciences
Coronary artery disease: Clinical sciences
Atherosclerosis and arteriosclerosis: Pathology review

Decision-Making Tree

Transcript

Watch video only

Developmental milestones during the first years of life are crucial for lifelong development and learning. These milestones are functional skills that follow a predictable sequence by specific ages, and are divided into five major categories: gross motor development, which relates to the movement of large muscles; fine motor development, which relates to the movement of small muscles; cognitive development, which covers reasoning, memory, and problem-solving; social-emotional development, which describes attachment to and interactions with others; and finally, language development, which covers both receptive and expressive communication.

Understanding normal developmental milestones will help you recognize when a child could be at risk for a developmental delay. Early intervention services can then be implemented to improve developmental outcomes.

When an infant presents for assessment of their developmental milestones, you should begin your examination with a focused history and physical exam. During the history portion, be sure to review birth history, including gestational age and birth weight; and remember to ask about family history of developmental delays. You should also take an interval history by asking the family what new skills their baby has learned since the last clinic visit. Additionally, ask the caregiver if they have any concerns about their baby’s development; since they spend the most time with their baby, they are often the first to notice when something isn’t quite right.

Now, here’s a clinical pearl to keep in mind! If the caregiver has a concern about their baby’s development, that’s a red flag; so, during your assessment, pay special attention to the caregiver’s concern!

The examination is also an opportune time for you to see first-hand what the baby can do. During your exam, take some time to play with the baby. A playful and interactive exam is entertaining for the infant and gives you a snap-shot of the baby’s development.

Now, at each visit, your goal is to assess the infant’s developmental milestones according to their age, using a combination of direct observation and caregiver reports. Shortly after birth, you should assess their neurologic and motor development by checking reflexes that are present in the neonatal period. For example, you can check for the rooting reflex by stroking the side of the newborn’s mouth or cheek, and in response, they should turn their head towards your hand while opening their mouth. After they open their mouth, you can check for the suck reflex by placing a gloved finger in their mouth and touching the roof of their mouth. Normally, an infant should begin sucking.

Finally, don’t forget to assess the Moro reflex, also called the startle reflex. You can trigger the Moro reflex with sudden movements or loud sounds; or, you can hold the baby horizontally and make a dropping motion with your hands. In response, the baby should throw back their head, extend out their arms and legs, cry, and then pull their arms and legs back in.

In addition to assessing developmental milestones, you should assess for red flags that may signal the risk of a developmental delay. These include prematurity, low birth weight, and caregiver indifference, meaning a caregiver that is not responsive to their newborn.

Now, let’s move on to the developmental milestones you should see in a one-month-old! Gross motor milestones include being able to lift their chin during tummy time, or the time they spend on their tummies; turning their head to both sides when laying on their backs; and moving both of their arms and legs equally. Fine motor milestones include keeping their hands fisted and near their face.

Cognitive skills include looking at faces. As far as social-emotional development goes, they recognize their caregiver’s voices, and they cry when distressed. Lastly, important language milestones include startling to loud sounds and making throaty noises.

Red flags you should look for include poor movement or feeding due to low muscle tone; not responding to loud sounds or focusing on objects within a few inches from their face; and caregiver indifference.

Okay, moving on to a two-month-old. By this time, the infant’s gross motor development includes being able to lift their head and chest when on their tummies; although their head lags when they’re supported in a sitting position. Fine motor skills include unfisted hands nearly half of the time and the ability to hold their hands together at midline.

Cognitive skills include opening their mouth when they see a breast or bottle, recognizing their caregiver, and looking at toys that are presented to them. Social-emotional development includes a reciprocal smile, which is when the infant smiles in response to their caregiver’s smile; and important language skills include cooing, which consists of vowel sounds like “ooh” and “aah;” and making sounds in response to their caregivers.

Red flags you should look for include not lifting their head during tummy time; and not looking at faces or responding to voices.

Now, let’s switch gears and discuss milestones for a four-month-old. In this case, the gross motor milestones include propping themself up on their wrists during tummy time, holding their head up straight and steady when sitting with support; and rolling from prone to supine. Fine motor skills at this age include open, unfisted hands most of the time. The infant also enjoys reaching for objects and playing with a rattle.

Sources

  1. "Evidence-Informed Milestones for Developmental Surveillance Tools" Pediatrics (2022)
  2. "Developmental Milestones" Pediatr Rev (2016)
  3. "Nelson Textbook of Pediatrics, 21st ed. " Elsevier (2020)