McCune-Albright syndrome
Summary of McCune-Albright syndrome
McCune-Albright syndrome is characterized by the triad of patchy skin pigmentation, bone abnormalities, and endocrine hormonal abnormalities. It is a result of a random mutation in the GNAS gene involved in G-protein signaling. It presents with large cafe-au-lait (light brown) spots, multiple endocrine abnormalities, precocious puberty, and polyostotic fibrous dysplasia.